Structure-Activity Correlationship and Strain Specificity of Polyoxometalates in Anti-human Immunodeficiency Virus Activity
スポンサーリンク
概要
- 論文の詳細を見る
The anti-human immunodeficiency virus (HIV) activity of polyoxometalates of representative structural families, such as Keggin, lacunary Keggin, trivacant Keggin, Keggin sandwich, Wells-Dawson and Wells-Dawson sandwich, was determined using two strains of HIV type 1 (HIV-1_<HTLV-IIIB>and HIV-1_<SF-2H>). The compounds were preferably selected to cover both polyoxotungstates and polyoxomolybdates in each structural family. In general, polyoxotungstates of Keggin, lacumary Keggin, trivacant Keggin, Keggin sandwich, Wells-Dawson and Wells-Dawson sandwich structures showed anti-HIV-1_<HTLV-IIIB>activity, whereas most compounds not included in these structural categories were inactive. Among the compounds with a potent anti-HIV-1_<HTLV-IIIB>activity, those of Keggin and its closely related structural families (lacunary Keggin, trivacant Keggin and Keggin sandwich) inhibited the cytopathogenicity and syncytium formation caused by HIV-1_<SF-2H>to a much higher extent compared with HIV-1_<HTLV-IIIB>-related ones. The difference between the spectra of anti-HIV-1_<HTLV-IIIB>activity and the specificity for HIV-1_<SF-2H>might result from differential structural requirements in these functions.
- 公益社団法人日本薬学会の論文
- 1995-07-15
著者
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杉山 政則
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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藤本 康弘
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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吉田 隆志
Department Of Pharmacognosy College Of Pharmaceutical Sciences Matsuyama University
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井上 義雄
科学警察研究所
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Inouye Y
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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井上 義雄
広島大学医学部
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吉田 哲也
広島大学医学部
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井上 義雄
Institute of Pharmaceutical Science Hiroshima University School of Medicine
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吉田 哲也
Department of Microbiology Hiroshima University School of Medicine
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山瀬 利博
Research Laboratory Of Resources Utilization Tokyo Institute Of Technology
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Yamase T
Research Laboratory Of Resources Utilization Tokyo Institute Of Technology
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Fujimoto Y
Department Of Biochemistry Hokkaido College Of Pharmacy
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