Activation of the Aryl Hydrocarbon Receptor by Some Vegetable Constituents Determined Using in Vitro Reporter Gene Assay
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概要
- 論文の詳細を見る
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the biological action of many aromatic environmental pollutants. In this study, we investigated the activation of the AhR by some vegetable constituents using the AhR-based bioassay for dioxins, I.e,, the chemical activated luciferase gene expression (CALUX) assay. Ninety-five vegetable constituents, including flavonoids, tannins, saponins, and terpenes, were tested in vitro. Among them, isoflavones such as daidzcin, resveratrol having a stilbcne structure, and some flavonoids such as naringenin, hesperetin, and baicalein showed AhR activation.
- 社団法人日本薬学会の論文
- 2003-04-01
著者
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吉田 隆志
Department Of Pharmacognosy College Of Pharmaceutical Sciences Matsuyama University
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SASAKI Kumiko
National Institute of Health Sciences
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YOSHIDA Takashi
Faculty of Pharmaceutical Sciences, Matsuyama University
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Amakura Yoshiaki
Division of Foods, National Institute of Health Sciences
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Tsutsumi Tomoaki
Division of Foods, National Institute of Health Sciences
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Sasaki Kumiko
Division of Foods, National Institute of Health Sciences
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Nakamura Masafumi
Hiyoshi Corporation
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Maitani Tamio
Division of Foods, National Institute of Health Sciences
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Tsuchiya T
Department Of Molecular Microbiology Graduate School Of Medicine Dentistry And Pharmaceutical Scienc
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Tsuchiya Tomofusa
岡山大学 分子微生物学
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Sasaki K
Division Of Foods National Institute Of Health Sciences
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Nakamura M
Hiyoshi Corporation
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TSUTSUMI Tmoaki
Division of Foods, National Institute of Health Sciences
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NAKAMURA Msafumi
Hiyoshi Corporation
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KITAGAWA Hiroko
Hiyoshi Corporation
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FUJINO Junko
Hiyoshi Corporation
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TOYODA Masatake
Faculty of Human Life Sciences, Jissen Women's University
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Toyoda M
Jissen Women's Univ.
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Toyoda Masatake
Faculty Of Human Life Sciences Jissen Women's University
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Yoshida T
Hokuriku Seiyaku Co. Ltd. Fukui Jpn
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Yoshida T
Department Of Microbiology Hiroshima University School Of Medicine
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Amakura Yoshiaki
Department Of Pharmacognosy College Of Pharmaceutical Sciences Matsuyama University
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Takagi Miyuki
Faculty Of Pharmacy Chiba Institute Of Science
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Machiguchi Takahisa
Faculty Of Science Saitama University
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Maitani Tamio
Division Of Foods National Institute Of Health Sciences
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吉田 隆志
College Of Pharmaceutical Sciences Matsuyama University
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Yoshida Takuji
Showa Pharmaceutical University
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Toyoda M
National Institute Of Health Sciences
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米谷 民雄
Division Of Foods National Institute Of Health Sciences
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Takeda Mitsuharu
College Of Bioresource Sciences Nihon University
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Yoshida Takashi
Faculty Of Agriculture Kyusyu University
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Toyoda M
Department Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Kyoto University
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Tanabe Tomotaka
College Of Pharmaceutical Sciences Matsuyama University
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Yoshida Takashi
Faculty Of Agriculture And Life Science Hirosaki University
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Nakamura M
Faculty Of Pharmaceutical Sciences Fukuoka University
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Amakura Yosiaki
Division of Foods, National Institute of Health Sciences
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