Beta-Carboline Alkaloids in Crude Drugs

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概要

• 論文の詳細を見る

• Beta-carboline alkaloids in crude drugs were quantified by a reversed-phase HPLC method without interference from their artifactual formation during analysis and with fluorometric detection specific to each individual analyte. 1-Methyl-β-carboline, β-carboline, 7-hydroxy-1-methyl-β-carboline, 7-methoxy-1-methyl-β-carboline, 1-methyl-1,2,3,4-tetrahydro-β-carboline and 1,2,3,4-tetrahydro-β-carboline showed a wide distribution in the crude drugs and the former two β-carbolines were detected in all those tested. Schisandrae Fructus, Pinelliae Tuber, Evodiae Fructus and Passiflora incarnata contained relatively large amounts of β-carbolines at ng-μg/g dry weight levels. Beta-carboline alkaloids may be responsible for the pharmacological effects of crude drugs as the potent active substances.

• 社団法人日本薬学会の論文
• 1999-03-15

著者

• IINUMA Munekazu

  Gifu Pharmaceutical University

• Shimizu Hiroshi

  Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osak

• Hatano Tsutomu

  エジプト

• Hatano Tsutomu

  Division Of Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pha

• Iinuma M

  Gifu Pharmaceutical University

• 土屋 博紀

  Asahi Univ. School Of Dentistry Gifu Jpn

• 土屋 博紀

  朝日大学歯学部口腔細菌学講座

• TSUCHIYA Hironori

  Department of Dental Pharmacology, Asahi University School of Dentistry

• Shimizu Hiroshi

  Department Of Bioinformatic Engineering Graduate School Of Information Science And Technology Osaka

• Tsuchiya Hironori

  Department Of Dental Basic Education Building 3 Asahi University School Of Dentistry

• Shimizu Hiroshi

  Department Of Animal Science Faculty Of Agriculture Hokkaido University

• Iinuma Munekazu

  Gifu Pharmaceutical Univ.gifu Jpn

• SHIMIZU HIROSHI

  Department of Anatomy, School of Medicine, Tokushima University

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