Analysis of Hemin Effect on Lactate Reduction in Lactococcus lactis(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
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概要
- 論文の詳細を見る
Lactococcus lactis is a facultative anaerobic microorganism that produces lactate as the major product, and acetate and acetoin as by-products; some strains of this species produce an antimicrobial compound, nisin. Lactate has a strong inhibitory effect on L. lactis growth. On the other hand, hemin has a suppressive effect on lactate production during L. lactis growth under aerobic condition. To achieve the optimum effect of hemin on lactate amount reduction in L. lactis ATCC11454, cultures entailing various conditions were performed with and without hemin. In the culture with hemin, L. lactis growth and lactate reduction improved compared with those in the culture without hemin; that is, lactate production was suppressed by 1.8- and 1.3-fold under batch and fed-batch cultures, respectively. In microaerobic fed-batch culture with hemin, lactate production was sufficiently suppressed. This result suggests that microaerobic fed-batch culture could be applied to the maintenance of the low lactate amount. Under this condition, metabolic shift was observed from lactate to acetoin and acetate. However, no increase in nisin production was observed even though lactate production could significantly decrease in L. lactis ATCC11454.
- 社団法人日本生物工学会の論文
- 2007-06-25
著者
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SHIOYA SUTEAKI
Department of Biotechnology, Graduate School of Engineering, Osaka University
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Shimizu Hiroshi
Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osak
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Suzuki Shingo
Department Of Bioinformatic Engineering Graduate School Of Information Science And Technology Osaka
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NAGAHISA KEISUKE
Department of Biotechnology, Graduate School of Engineering, Osaka University
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Suzuki Shingo
Technology Osaka University
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Wardani Agustin
Department Of Biotechnology Graduate School Of Engineering Osaka University
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Nagahisa Keisuke
Department Of Bioinformatic Engineering Graduate School Of Information Science And Technology Osaka
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Nagahisa Keisuke
Department Of Bioinformatic Engineering Graduate School Of Information Science And Technology Osaka
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Shimizu Hiroshi
Department Of Bioinformatic Engineering Graduate School Of Information Science And Technology Osaka
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Shioya S
Department Of Biotechnology Graduate School Of Engineering Osaka University
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Shioya Suteaki
Department Of Biotechnology Graduate School Of Engineering Osaka University:(present Office)departme
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Shioya Suteaki
Technology Osaka University
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Shioya Suteaki
Department Of Biotechnology Faculty Of Engineering Osaka University
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Nagayasu Machiko
Department of Biotechnology, Graduate School of Engineering, Osaka University
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Nagahisa Keisuke
Department Of Bioinformatic Engineering Graduate School Of Information Science And Technology Osaka
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Shimizu Hiroshi
Department Of Animal Science Faculty Of Agriculture Hokkaido University
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Shimizu Hiroshi
Department Of Bioinformatic Engineering Graduate School Of Information Science And Technology Osaka
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Shimizu Hiroshi
Department Of Bioinformatic Engineering Graduate School Of Information Science And Technology Osaka
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Nagayasu Machiko
Department Of Biotechnology Graduate School Of Engineering Osaka University
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SHIMIZU HIROSHI
Department of Anatomy, School of Medicine, Tokushima University
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