Effect of Brefeldin-A on Compaction of Preimplantation Mouse Embryos

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概要

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• The effect of the protein transport inhibitor brefeldin A (BFA) on compaction of early mouse embryos was investigated morphologically and immunocytochemically. After placing 4- and 8-cell mouse embryos in a medium with BFA for 3 or 6 h, the features of compaction were investigated. It was found that the effects of BFA on compaction were dependent upon the cell stage when this drug was applied. Compaction was delayed when embryos were placed in BFA during the mid or late 8-cell stage (3-6 and 6-9 h post division to the 8-cell stage). In embryos treated with BFA, Roh-ConA binding was weakened and detected at the cell contact regions. The distribution of microvilli seemed to be altered. It was concluded that protein transport for compaction was initiated at the early 8-cell stage just before the development of the compacted state.

• 日本繁殖生物学会の論文
• 1997-11-01

著者

• 清水 博

  東大

• 清水 博

  東京大学・薬学部

• 清水 博

  東大・薬

• 清水 博

  東大薬

• Shimizu Hiroshi

  Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osak

• MORI Tadashi

  Department of Internal Medicine, Karatsu Red Cross Hospital

• Ogawa Hidehiko

  Department of BioScience, Tokyo University of Agriculture BRAIN

• Shimizu Hiroshi

  Department Of Bioinformatic Engineering Graduate School Of Information Science And Technology Osaka

• Ogawa H

  Reproductive Biology And Technology Research Team National Institute Of Livestock And Grassland Scie

• Mori Tadashi

  Department Of Animal Science Faculty Of Agriculture Hokkaido University

• Ogawa Hidehiko

  Department Of Animal Science Faculty Of Agriculture Hokkaido University

• Shimizu Hiroshi

  Department Of Animal Science Faculty Of Agriculture Hokkaido University

• SHIMIZU HIROSHI

  Department of Anatomy, School of Medicine, Tokushima University

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