Chemical Behavior of 2'-Vinyl-2H-benzothiazine-2-spirocyclopropan-3(4H)-ones in Acidic Media

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概要

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• Reactions of 2'-vinyl-2H-benzothiazine-2-spirocyclopropan-3(4H)-ones (1) with several proton acids were examined. Reactions of 1 with HCl and HBr predominantly gave (Z)-allyl halide derivatives (2). In the cases of HClO_4 and HBF_4 4,4a, 5,6-tetrahydro-5-oxo-1H-thiopyrano[1,2-a]-1,4-benzothiazinium salts (3) were isolated. Allyl halides (2) were also obtained by treatment of the salts (3) with HCl and HBr.

• 公益社団法人日本薬学会の論文
• 1998-01-15

著者

• 清水 博

  東大

• 清水 博

  東京大学・薬学部

• 清水 博

  東大・薬

• 清水 博

  東大薬

• Iwama Tetsuo

  Gifu Pharmaceutical University

• KATAOKA Tadashi

  Gifu Pharmaceutical University

• NAKAMURA Yoshihide

  Gifu Pharmaceutical University

• MATSUMOTO Harutoshi

  Gifu Pharmaceutical University

• SHIMIZU Hiroshi

  Gifu Pharmaceutical University

• Iwamura T

  Gifu Pharmaceutical Univ. Gifu Jpn

• KONDO Hirohito

  Gifu Pharmaceutical University

• Matsumoto H

  Yamanouchi Pharmaceutical Co. Ltd. Ibaraki Jpn

• Kataoka T

  Gifu Pharmaceutical Univ. Gifu Jpn

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