Maximum Histidine Production by Fed-Batch Culture of Brevibacterium flavum
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概要
- 論文の詳細を見る
In this paper, an approach for the maximum production of histidine in fed-batch culture was proposed and its validity was shown from the experiental data. The approach was based on the model which describes the relationship between specific production rate, ρ, and specific growth rate, μ. Using a mathematical model, an optimal profile of the specific growth rate could be obtained easily by the Maximum Principle. Finally, the optimal profile was realized by changing the feed rate of substrate in a practical fed-batch culture. The maximum production of histidine could be attained by this procedure. The specific histidine production rate, ρ_H, had the maximum at a certain specific growth rate, μ_C, and the optimal profile was obtained as the bang-bang control (boundary control). That is, in the early stage of the fed-batch culture μ should be kept at its maximum value, μ_<max> and for the next stage μ should be kept at μ_C. The control strategy can be comprehended as a two-stage production procedure composed of a cell growth stage and then a production stage. The two-stage production process of histidine could be realized experimentally and the validity of the proposed method was shown.
- 社団法人日本生物工学会の論文
- 1991-03-25
著者
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SHIOYA SUTEAKI
Department of Biotechnology, Graduate School of Engineering, Osaka University
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Suzuki Shingo
Department Of Bioinformatic Engineering Graduate School Of Information Science And Technology Osaka
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SUGA KEN-ICHI
Department of Biotechnology, Faculty of Engineering, Osaka University
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Suzuki Shingo
Technology Osaka University
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Suga K
Osaka Univ. Osaka Jpn
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Suga K
Department Of Biotechnology Graduate School Of Engineering Osaka University
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Suga K
Osaka Univ. Osaka
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Suga Ken-ichi
Department Of Biological Science And Technology Science University Of Tokyo
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Shioya S
Department Of Biotechnology Graduate School Of Engineering Osaka University
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Shioya Suteaki
Department Of Biotechnology Graduate School Of Engineering Osaka University:(present Office)departme
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Shioya Suteaki
Department Of Biotechnology Faculty Of Engineering Osaka University
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Shioya Suteaki
Department Of Fermentation Technology Osaka University
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CHIM-ANAGE PATOOMPORN
Department of Microbiology, Gaculty of Science, Kasetsart University
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Chim‐anage P
Kasetsart Univ. Bangkok Tha
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Chim-anage Patoomporn
Department Of Fermentation Technology Osaka University
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