Optimal Control of an Immobilized Enzyme Reactor

概要

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Optimal process countrol of an immobilized enzyme reactor subject to enzyme deactivation has been studied using a microcomputer for optimum continuous temperature control with a sample-data control technique. The optimum conversion and temperature program for experiments were determined by the maximum principle.The temperature control was carried out according to the calculated optimum temperature program based on the parameters estimated from preliminary experiments. Simultaneously, the reaction mixture was sampled with a predetermined sampling period for measurement of the conversion. When the deviation between the calculated optimum conversion and the experimental conversion exceeded the allowable range, the optimum operation policy was amended based on new parameters estimated using the data obtained by that time.The effects of measurement error and sampling period on the optimum profit were statistically investigated by the simulation of the immobilized enzyme process subject to enzyme deactivation. As a result, it has been concluded that a sampling period of 6 hr can allow precise enough estimation for the actual control experiment with 0.007 standard deviation of measurement error.
社団法人日本生物工学会の論文
1981-10-25