Optimal Operation and Replacement Policies for a Reactor with Immobilized Enzymes Subject to Deactivation

概要

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A search method for finding the optimal temperature progression and optimal replacement time for the immobilized enzyme process of glucose isomerization was developed according to Pontryagin's Maximum Principle. The optimal operation policy adopted as a result of the proposed optimization method is constant conversion followed by falling conversion. The method is applied to the general case of a reversible reaction which occurs in the presence of immobilized enzyme being deactivated by an irreversible first order mechanism. When it is possible for the reactor capacity to be large enough, the largest allowable particle size as well as the lowest allowable initial temperature will favor the maximum profit with the optimal replacement time. However, for a short specified shoutdown time, the smallest particle yields the maximum profit at a high initial temperature. And for long-term operation, the optimal particle size is dependent on the length of the shoutdown time.
社団法人日本生物工学会の論文
1981-04-25