Inhibitory Effects of Flavonoid Glycosides Isolated from the Peel of Japanese Persimmon (Diospyros kaki ‘Fuyu’) on Melanin Biosynthesis

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概要

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• We found that the acetone extract of the peel of Japanese persimmon (Diospyros kaki ‘Fuyu’) inhibits melanin biosynthesis in mouse B16 melanoma cells. The activity-guided purification of the extract resulted in isolation of two active compounds, which have been identified as flavonoid glycosides, isoquercitrin (quercetin-3-O-glucoside) and hyperin (quercetin-3-O-galactoside) by spectral analysis. Isoquercitrin and hyperin strongly inhibited the production of melanin (IC50: 21.7 and 18.2 μM, respectively). The inhibitory effects were found to be mediated by suppression of tyrosinase expression.

著者

• IINUMA Munekazu

  Gifu Pharmaceutical University

• Nozawa Yoshinori

  Gifu International Institute of Biotechnology

• Ohguchi Kenji

  Gifu International Institute of Biotechnology

• AKAO Yukihiro

  Gifu International Institute of Biotechnology

• OYAMA Masayoshi

  Gifu Pharmaceutical University

• Itoh Tomohiro

  Gifu International Institute Of Biotechnology

• Iinuma Munekazu

  Gifu Pharmaceutical Univ.gifu Jpn

• Ito Masafumi

  Gifu International Institute of Biotechnology

• Nakajima Chizuru

  Gifu Pharmaceutical University

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