Lig-8, a Bioactive Lignophenol Derivative From Bamboo Lignin, Protects Against Neuronal Damage In Vitro and In Vivo
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概要
- 論文の詳細を見る
Lig-8, a lignophenol derivative from bamboo lignin, potently suppresses oxidative stress-induced apoptosis. Here, we first examined in vitro whether lig-8 protects against neuronal damage induced by oxygen-glucose deprivation (OGD) followed by reoxygenation, tunicamycin [endoplasmic reticulum (ER)-stress inducer], or PSI (proteasome inhibitor). In pheochromocytoma (PC12) cell cultures, lig-8 (1 to 30 μM) concentration-dependently inhibited OGD- and tunicamycin (2 μg/ml)-induced cell deaths (significant at ≥3 μM and ≥1 μM, respectively). In human neuroblastoma (SH-SY5Y) cell culture, the PSI-induced apoptotic cell death and fusion protein accumulation (revealing reduced proteasome activity) was inhibited by lig-8 (30 μM). On the other hand, lig-8 at 30 μM alone did not affect any proteasome activity under resting conditions. In vivo, lig-8 (0.1 nmol/eye) reduced intravitreal N-methyl-<sc>D</sc>-aspartate (NMDA, 20 nmol)-induced retinal damage (decreases in retinal ganglion cells and inner plexiform layer thickness). Hence, lig-8 protects, partly by inhibiting excessive ER-stress, against neuronal damage in vitro and in vivo.
- 社団法人 日本薬理学会の論文
- 2006-10-20
著者
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ITO Yasushi
Department of Neurosurgery, Brain Research Institute, Niigata University
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Nozawa Yoshinori
Gifu International Institute of Biotechnology
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AKAO Yukihiro
Gifu International Institute of Biotechnology
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Hara Hideaki
Department Of Biofunctional Evaluation Molecular Pharmacology Gifu Pharmaceutical University
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SHIMAZAWA Masamitsu
Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University
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Ito Yasushi
Department Of Neurosurgery Brain Research Institute University Of Niigata
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Seki Norio
Gifu Prefectural Research Institute For Human Life Technology
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NAKAJIMA Yoshimi
Department of Biofunctional Molecules, Gifu Pharmaceutical University
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Shimazawa Masamitsu
Department Of Biofunctional Evaluation Molecular Pharmacology Gifu Pharmaceutical University
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Shimazawa Masamitsu
Department Of Biofunctional Molecules Gifu Pharmaceutical University
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Ito Yasushi
Department Of Biological Diversity Faculty Of Agriculture Gifu University
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Ito Yasushi
Department Of Biofunctional Molecules Gifu Pharmaceutical University
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Nakajima Yoshimi
Department Of Biofunctional Molecules Gifu Pharmaceutical University
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ITO Yasushi
Department of Applied Chemisty, Faculty of Technology, Tokyo University of Agriculture and Technology
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