Effect of nimodipine on ischemia-induced brain edema and mortality in a novel transient middle cerebral artery occlusion model.
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概要
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A novel transient middle cerebral artery (MCA) occlusion model in the rat was used to evaluate the effect of nimodipine on brain edema and mortality. Nimodipine (30 μg/kg) administered immediately after 3 hr of transient unilateral MCA occlusion attenuated significantly the post-ischemic increase of tissue water content and partly attenuated <SUP>45</SUP>Ca accumulation in the parieto-temporal cortex ipsilateral to the left MCA occlusion 3 hr after reperfusion. Nimodipine decreased the mortality rate at 6 and 9 hr after recirculation, although the survival rate at 24 hr after recirculation was not different from the control group. These results suggest that nimodipine has beneficial effects in the early phase of the reperfusion period.
- 公益社団法人 日本薬理学会の論文
著者
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Hara Hideaki
Department Of Biofunctional Evaluation Molecular Pharmacology Gifu Pharmaceutical University
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Onodera Hiroshi
Department Of Neurology Tohoku University School Of Medicine
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ONODERA Hiroshi
Department of Neurology, Institute of Brain Diseases, Tohoku University School of Medicine
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KOGURE Kyuya
Department of Neurology, Institute of Brain Diseases, Tohoku University School of Medicine
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NAGASAWA Haruo
Department of Neurology, Institute of Brain Diseases, Tohoku University School of Medicine
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- Effect of nimodipine on ischemia-induced brain edema and mortality in a novel transient middle cerebral artery occlusion model.