4-Methoxyphenyl 4-(3,4,5-Trimethoxybenzyl)-1-Piperazineacetate Monofumarate Monohydrate (KB-5492), a New Anti-Ulcer Agent with a Selective Affinity for the Sigma Receptor, Prevents Cysteamine-Induced Duodenal Ulcers in Rats by a Mechanism Different from T
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概要
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Both KB-5492, a new anti-ulcer agent, and cimetidine, administered orally at 25-200 mg/kg, dose-dependently prevented cysteamine (400 mg/kg, s.c.)-induced duodenal ulcers in rats with ED<SUB>50</SUB> values of 63 and 40 mg/kg, respectively. Anti-ulcer doses of cimetidine, but not KB-5492, inhibited gastric acid hypersecretion induced by cysteamine (400 mg/kg, s.c.). In contrast, anti-ulcer doses of KB-5492, but not cimetidine, increased duodenal HCO<SUB>3</SUB><SUP>-</SUP> secretion in normal anesthetized rats. These findings suggest that KB-5492 prevents cysteamine-induced duodenal ulcers by stimulating duodenal HCO<SUB>3</SUB><SUP>-</SUP> secretion, whereas cimetidine does so by inhibiting cysteamine-induced gastric acid hypersecretion.
- 公益社団法人 日本薬理学会の論文
著者
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Hara Hideaki
Department Of Biofunctional Evaluation Molecular Pharmacology Gifu Pharmaceutical University
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Morimoto Yasuo
Department Of Chemical Engineering Osaka Prefecture University
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Sukamoto Takayuki
Department Of Pharmacology Jichi Medical School
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Tanaka Keiko
Department Of Anesthesiology Akashi Municipal Hospital
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SHIMOHARA Koichi
Department of Applied Pharmacology, Kyoto Pharmaceutical University
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Morimoto Yasuo
Department of Pharmacology, New Drug Research Laboratories, Kanebo, Ltd.
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Sukamoto Takayuki
Department of Pharmacology, New Drug Research Laboratories, Kanebo, Ltd.
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