Effects of KB-5492, 1-(3,4,5-trimethoxybenzyl)-4-((4-methoxyphenyl)oxycarbonylmethyl)piperazine monofumarate monohydrate, on gastric lesions and gastric secration in rats.
スポンサーリンク
概要
- 論文の詳細を見る
Effects of a newly synthesized compound, KB-5492, on gastric lesions and gastric secretion were studied in rats. Oral KB-5492 inhibited the lesions induced by HCl·ethanol, HCl·aspirin, water-immersion stress, indomethacin, histamine and prednisolone at 30-300 mg/kg. The ED50 values varied from about 35 to 98 mg/kg. KB-5492 had no effect on gastric acid secretion even at 300 mg/kg. KB-5492 appeared to have a much more potent protective effect than a known anti-ulcer drug, sofalcone, against acute gastric lesions.
- 公益社団法人 日本薬理学会の論文
著者
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Okabe Susumu
Department Of Applied Pharmacology Kyoto College Of Pharmacy
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Niida Hiromichi
Department of Applied Pharmacology, Kyoto Pharmaceutical University
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SHIMOHARA Koichi
Department of Applied Pharmacology, Kyoto Pharmaceutical University
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