Role of the Sympathetic Nervous System in Gastric Functional Changes Induced by Thyrotropin-Releasing Hormone in Rats
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概要
- 論文の詳細を見る
We determined the changes in gastric functions and systemic blood pressure in response to thyrotropin-releasing hormone (TRH) simultaneously in anesthetized rats and examined the role of the sympathetic nervous system in these changes. TRH injected i.c. increased gastric acid secretion, contraction and mucosal blood flow, and produced hemorrhagic lesions in the glandular stomach. These responses to TRH were almost completely inhibited by bilateral cervical vagotomy or atropine. The increased gastric acid secretion and contraction in response to TRH were significantly augmented by pretreatment with yohimbine but not with prazosin. Bilateral adrenalectomy also potentiated the gastric acid secretory and contractile responses to TRH. Neither prazosin, yohimbine nor adrenalectomy had any appreciable effect on the increased gastric mucosal blood flow induced by TRH. TRH-induced gastric mucosal lesions were significantly aggravated by yohimbine and adrenalectomy. In vagotomized rats, TRH significantly suppressed the gastric functional changes induced by electrical stimulation of the vagus nerves. These data suggest that while gastric functional changes and mucosal lesions induced by TRH mainly occur through stimulation of the vagus nerves, these responses are extensively modified by the sympathetic nervous system including the adrenal glands.
- 社団法人 日本薬理学会の論文
- 1995-02-01
著者
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Takeuchi Koji
Div. Of Pathological Sciences Dep. Of Pharmacology And Experimental Therapeutics Kyoto Pharmaceutica
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Okabe Susumu
Department Of Applied Pharmacology Kyoto College Of Pharmacy
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Takeuchi K
Global Warming Control Department National Institute For Resources And Environment
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Tachibana Masaki
Department Of Applied Chemistry And Biotechnology Faculty Of Engineering Yamanashi University
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Tachibana Masaki
Department Of Applied Pharmacology Kyoto Pharmaceutical University
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Takeuchi Koji
Department Of Applied Pharmacology Kyoto College Of Pharmacy
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Takeuchi Koji
Department of Air Pollution Control, National Research Institute for Pollution and Resources
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