STRAIN DIFFERENCES IN ASPIRIN-INDUCED GASTRIC ULCERATION IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
We found that there are strain differences in aspirin-induced ulceration in pylorus-ligated rats; the ulcer indices varied, from high to low, in the following order: Donryu>Sprague-Dawley>Wistar. Several experiments including analysis of gastric contents or ionic flux, determination of serum aspirin esterase activity, absorption of aspirin from the stomach, prothrombin time and hexosamine content in gastric mucosa and juice were performed to elucidate the origin of the differences. A significantly higher acid output in Donryu rats, and higher hexosamine content in the gastric mucosa of Wistar rats were noted. However, it appears unlikely that these factors only contribute to the marked strain difference in aspirin-induced ulcers. The possible different sensitivity of gastric mucosal cell itself to aspirin must be considered.
- 社団法人 日本薬理学会の論文
著者
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TAKEUCHI Koji
Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University
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Urushidani Tetsuro
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
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Okabe Susumu
Department Of Applied Pharmacology Kyoto College Of Pharmacy
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TAKAGI Keijiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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Takeuchi Koji
Department Of Applied Pharmacology Kyoto College Of Pharmacy
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Urushidani Tetsuro
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
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Takeuchi Koji
Department of Air Pollution Control, National Research Institute for Pollution and Resources
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TAKAGI Keijiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences University of Tokyo
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