EFFECTS OF L-GLUTAMINE ON ACETYLSALICYLIC ACID-INDUCED GASTRIC LESIONS IN NORMAL AND CIRRHOTIC RATS
スポンサーリンク
概要
- 論文の詳細を見る
Cirrhosis of the liver in rats was induced by the administration of carbon-tetrachloride (0.1 ml/100 g of body weight, s.c.) biweekly for 13 weeks. In the pylorus ligation preparation, acetylsalicylic acid (ASA) 100 mg/kg p.o. Induced much more serious gastric damage in CCl<SUB>4</SUB>-induced cirrhotic rats as compared with rats with a normal liver. L-glutamine 750 mg/kg p.o. prevented the ASA-induced gastric lesions in both normal and cirrhotic rats, even though the degree of the inhibition was weaker in cirrhotic rats. Gastric analysis indicated that L-glutamine 750 mg, , kg p.o. markedly inhibited the gastric ionic changes (acid back diffusion) in response to ASA in both cirrhotic and normal rats.
- 社団法人 日本薬理学会の論文
著者
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TAKEUCHI Koji
Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University
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OKABE Susumu
Department of Applied Pharmacology, Kyoto Pharmaceutical University
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Urushidani Tetsuro
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
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Okabe Susumu
Department Of Applied Pharmacology Kyoto College Of Pharmacy
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TAKAGI Keijiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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NAGANUMA Toshihiko
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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Takeuchi Koji
Department Of Applied Pharmacology Kyoto College Of Pharmacy
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