Inhibition of Concanavalin A-Induced Mice Hepatitis by Coumarin Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
The effects of coumarin derivatives, osthole, imperatorin, Pd-Ia, Pd-II and Pd-III, on mice concanavalin A (Con A) (0.2 mg/mouse, i.v.)-induced hepatitis were studied. At the dose of 200 mg/kg (i.p.), these coumarins inhibited more than 90% of the Con A-induced elevation of plasma alanine aminotransferase activity, but glycyrrhizin (200 mg/kg, i.p.) caused only 45% inhibition. At the dose of 100 mg/kg (i.p.), osthole produced the strongest inhibition among these coumarins. The inhibitory activity of osthole is lost when its 7-methoxy group is replaced by a 7-hydroxy group to form osthenol. The present results showed that coumarin derivatives inhibited Con A-induced hepatitis, with osthole being the most inhibitory.
- 社団法人 日本薬理学会の論文
- 2001-01-01
著者
-
Kobayashi Tadashi
Research Institute of Angiocardiology and Cardiovascular Clinic, Kyushu University
-
Okabe Susumu
Department Of Applied Pharmacology Kyoto College Of Pharmacy
-
Kobayashi Tadashi
Research Laboratories Nippon Chemiphar Co. Ltd.
-
OKAMOTO Tosihihiro
Research Laboratories, Nippon Chemiphar Co., Ltd.
-
YOSHIDA Shinichi
Research Laboratories, Nippon Chemiphar Co., Ltd.
-
Yoshida Shinichi
Research Laboratories Nippon Chemiphar Co. Ltd.
-
Kobayashi Tadashi
Research Institute Of Angiocardiology And Cardiovascular Clinic Kyushu University
-
Kobayashi Tadashi
Research Laboratories, Nippon Chemiphar Co., Ltd.
関連論文
- PATHOPHYSIOLOGY OF HISTAMINE-INDUCED CORONARY ARTERY SPASM : IN VITRO AND IN VIVO ANALYSIS OF REGIONAL CORONARY HYPERCONTRACTION : Blood Vessels : FREE COMMUNICATIONS (I) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCI
- Utilization of Knockout Mice to Examine the Potential Role of Gastric Histamine H_2-Receptors in Menetrier's Disease
- Examination of Surface-Roughness of Silicon Crystals by Double-Crystal X-Ray Topography
- Desensitization of Capsaicin-Sensitive Sensory Neurons in Rat Stomachs on Chronic Treatment with Sodium Taurocholate
- Enhanced Gastric Mucosal Damage in Rats after Chronic Treatment with Sodium Taurocholate
- Induction of CPP32-Like Activity and Inhibition of Interleukin 1β Converting Enzyme Activity in the Liver of a Mouse Concanavalin A-Induced Hepatitis Model
- Expression of Cytokine mRNA in Extrahepatic Organs in a Mouse Concanavalin A-Hepatitis Model
- An Overview of Acetic Acid Ulcer Models : The History and State of the Art of Peptic Ulcer Research
- THE MECHANISM OF AGGRAVATION OF INDOMETHACIN-INDUCED GASTRIC ULCERS BY ADRENALECTOMY IN THE RAT
- On theMechanisms Underlying Histamine Induction of Gastric Mucosal Lesions in Rats With Partial Gastric Vascular Occlusion
- EFFECTS OF METIAMIDE AND PROPRANOLOL ON GASTRIC SECRETION IN ANESTHETIZED DOGS
- INFLUENCE OF AMYLOPECTINE SULFATE ON GASTRIC MUCOSA IN NORMAL OR WATER-IMMERSION STRESSED RATS
- EFFECTS OF L-GLUTAMINE ON ACETYLSALICYLIC ACID OR TAUROCHOLIC ACID-INDUCED GASTRIC LESIONS AND SECRETORY CHANGES IN PYLORUS-LIGATED RATS UNDER NORMAL OR STRESS CONDITIONS
- EFFECT OF L-GLUTAMINE ON ACETYLSALICYLIC ACID-INDUCED GASTRIC LESIONS IN PREGNANT AND NON-PREGNANT RATS
- EFFECTS OF L-GLUTAMINE ON ACETYLSALICYLIC ACID-INDUCED GASTRIC LESIONS IN NORMAL AND CIRRHOTIC RATS
- STIMULATORY EFFECT OF THE WATER EXTRACT OF BAMBOO GRASS (FOLIN SOLUTION) ON GASTRIC ACID SECRETION IN PYLORUS-LIGATED RATS
- EFFECTS OF PHENTOLAMINE MESYLATE AND PROPRANOLOL HYDROCHLORIDE ON ASPIRIN-INDUCED GASTRIC LESIONS AND GASTRIC SECRETION IN THE RAT
- PATHOGENESIS OF GASTRIC LESIONS INDUCED BY ASPIRIN IN THE PYLORUS-LIGATED RAT
- Changes in Gastric Function and Healing of Chronic Gastric Ulcers in Aged Rats
- CHARACTERISTICS OF MILD IRRITANTS AND ADAPTIVE CYTOPROTECTION ; ROLE OF ENDOGENOUS PROSTAGLANDINS IN SELF-DEFENSIVE MECHANISMS
- CHANGES IN TRANSMUCOSAL POTENTIAL DIFFERENCE AND LUMINAL PH IN ANESTHETIZED RAT STOMACH AFTER EXPOSURE TO ETHANOL
- EFFECTS OF VARIOUS DRUGS AND VAGOTOMY ON INDOMETHACIN-INDUCED GASTRIC ULCERS IN THE RAT
- Exogenous Histamine Stimulates Colorectal Cancer Implant Growth via Immunosuppression in Mice
- Roxatidine-and Cimetidine-Induced Angiogenesis Inhibition Suppresses Growth of Colon Cancer Implants in Syngeneic Mice
- EFFECTS OF AN ANTIULCER AGENT, N-ACETYL-L-GLUTAMINE ALUMINUM COMPLEX (KW-110) ON THE DUODENAL AND GASTRIC ULCER MODELS IN THE RAT
- Effects of Transforming Growth Factor Alpha and Hepatocyte Growth Factor on Acid-Induced Damage in Rat Gastric Epithelial Cells
- EFFECT OF OMEPRAZOLE ON MORPHOLOGICAL AND FUNCTIONAL CHANGES OF THE GASTRIC MUCOSA IN H. PYLORI-INFECTED MONGOLIAN GERBILS
- Roles of Gastric Motility Changes in Cytoprotection Induced by Acetazolamide and Cysteamine in Rats
- EFFECTS OF N-ACETYL-L-CARNOSINE ALUMINUM (CL-1700) ON VARIOUS ACUTE GASTRIC LESIONS AND GASTRIC SECRETION IN RATS
- STRAIN DIFFERENCES IN ASPIRIN-INDUCED GASTRIC ULCERATION IN RATS
- EFFECTS OF VARIOUS AMINO ACIDS ON INDOMETHACIN-INDUCED GASTRIC ULCERS IN RATS
- EFFECTS OF THE ANTIULCER DRUG GERANYLGERANYLACETONE ON ASPIRIN-INDUCED GASTRIC ULCERS IN RATS
- THE THERAPEUTIC EFFECT OF FM100, A FRACTION OF LICORICE ROOT, ON ACETIC ACID ULCER IN RATS
- ACID BACK-DIFFUSION AND MUCOSAL H+ HANDLING IN THE RAT STOMACH UNDER NORMAL AND STRESS-INDUCED CONDITIONS
- EFFECTS OF ANTI-ULCER AGENTS ON THERMAL-CORTISONE-INDUCED ULCERS IN RATS
- EFFECTS OF 15(S)-15-METHYL-PGE2 METHYL ESTER ON HEALING OF CHRONIC GASTRIC AND DUODENAL ULCERS IN RATS
- EFFECT OF L-GLUTAMINE ON INDOMETHACIN-INDUCED GASTRIC LESIONS IN THE RAT
- INFLUENCE OF SURGICAL SYMPATHECTOMY ON GASTRIC SECRETION AND ULCERATION IN RATS
- EFFECTS OF CL-1700 ON DUODENAL ULCER FORMATION IN THE RAT
- Role of Thromboxane A_2 in Healing of Gastric Ulcers in Rats
- Mucosal Protective Effect of Leminoprazole on Reflux Esophagitis Induced in Rats
- Recent Advances in Gastrointestinal Pathophysiology : Role of Heat Shock Proteins in Mucosal Defense and Ulcer Healing
- Inhibition of Concanavalin A-Induced Mice Hepatitis by Coumarin Derivatives
- GASTRIC ACID SECRETION IN BEAGLE DOGS USING INTRAMUSCULAR INJECTION OF STIMULANTS
- EFFECTS OF CL-1700 AND ITS CONSTITUENTS ON ACUTE OR CHRONIC GASTRIC LESIONS AND GASTRIC SECRETION IN RATS
- Role of the Sympathetic Nervous System in Gastric Functional Changes Induced by Thyrotropin-Releasing Hormone in Rats
- EFFECTS OF L-GLUTAMINE ON ACETYLSALYCYLIC ACID INDUCED GASTRIC LESIONS AND ACID BACK DIFFUSION IN DOGS
- Effects of Concanavalin A on Cytokine mRNA Expression in Mouse Liver
- Antisecretory Effect of Leminoprazole on Histamine - Stimulated Gastric Acid Secretion in Dogs: Potent Local Effect
- Effects of Immunosuppressants on Concanavalin A-Induced Interleukin-2 mRNA Expression in Mouse Liver
- INFLUENCE OF L-GLUTAMINE ON ASPIRIN-INDUCED GASTRIC LESIONS AND ABSORPTION AS WELL AS ANTIPYRETIC, ANALGESIC AND ANTI-INFLAMMATORY EFFECTS OF ASPIRIN IN RATS AND MICE
- Effect of omeprazole on delayed healing of acetic acid-induced gastric ulcers in rats.
- A continuous monitoring of mucosal integrity and secretory activity in rat stomach: A preparation using a lucite chamber.
- Effects of 15(R)-15-methyl prostaglandin E2 (arbaprostil) on gastric secretion and various gastric lesions induced in rats.
- Pathogenic mechanisms involved in mepirizole-induced duodenal damage in the rat.
- Impairment of acid-neutralizing capacity and lesion formation in the rat duodenum during hemorrhagic shock : Comparative study with indomethacin.
- Gastroduodenal HCO3- secretion in anesthetized rats: Effects of 16,16-dimethyl PGE2, topical acid and acetazolamide.
- Augmentation of cysteamine and mepirizole-induced lesions in the rat duodenum and stomach by histamine or indomethacin.
- Effects of indomethacin on the duodenal mucosa of rats : Comparative study with cysteamine.
- Effects of a New Histamine H2-Receptor Antagonist, Z-300, on Gastric Secretion and Gastro-Duodenal Lesions in Rats: Comparison with Roxatidine.
- Effect of NC-1300-O-3 on Healing of Acetic Acid-Induced Gastric Ulcers in Rats.
- Functional and morphological alterations in the rat stomach following exposure to hypertonic NaCl solution.
- Duodenal Ulcers Induced by Diethyldithiocarbamate, a Superoxide Dismutase Inhibitor, in the Rat: Role of Antioxidative System in the Pathogenesis.
- Cytoprotective action of histamine against 0.6N HCl-induced gastric mucosal injury in rats; Comparative study with adaptive cytoprotection induced by exogenous acid.
- Cytoprotective action of mast cell stabilizers against ethanol-induced gastric lesions in rats.
- Effects of prostaglandin biosynthesis inhibitors and ouabain on duodenal mucosa and HCO3- secretion in rats.
- Effects of topical application of acidified omeprazole on acid secretion and transmucosal potential difference in anesthetized rat stomachs.
- Mechanisms involved in aggravation of ethanol-induced gastric mucosal lesions in adrenalectomized rats.
- Stimulation by Capsaicin of Gastric Alkaline Secretion in Anesthetized Rats.
- Induction of Gastric Lesions by 2-Deoxy-D-Glucose in Rats Following Chemical Ablation of Capsaicin-Sensitive Sensory Neurons.
- Characterization of Gastric Mucosal Blood Flow Response Induced by Intragastric Capsaicin in Rats.
- Capsaicin-sensitive afferent neurons in adaptive responses of the rat stomach induced by a mild irritant.
- Gastric motility changes in capsaicin-induced cytoprotection in the rat stomach.
- Effects of orally administered human epidermal growth factor on natural and delayed healing of acetic acid-induced gastric ulcers in rats.
- Effects of Indomethacin and Prednisolone on the Different Stages of Healing of Acetic Acid-Induced Gastric Ulcers in the Rat.
- Effects of a crude extract of a marine dinoflagellate, containing dimethyl-.BETA.-propiothetin, on HClethanol-induced gastric lesions and gastric secretion in rats.
- Mechanism by Which Indomethacin Delays Gastric Ulcer Healing in the Rat: Inhibited Contraction of the Ulcer Base.
- Role of gastric acid and bile acids in the pathogenesis of Compound 48/80-induced gastric lesions in rats.
- Stimulation by prostaglandin E2 of alkaline secretion in the rat duodenum: Comparative study with hypertonic NaCl.
- Biochemical and pharmacological analysis of 2-((2-dimethylaminobenzyl)sulfinyl)benzimidazole (NC-1300), a new proton pump inhibitor.
- Capsaicin-Sensitive Sensory Nerves in Recovery of Gastric Mucosal Integrity after Damage by Sodium Taurocholate in Rats.
- Vinegar is a dietary mild irritant to the rat gastric mucosa.
- Effects of various agents on prednisolone-induced gastric lesions in rats.
- Effect of 16,16-dimethyl prostaglandin E2 on gastric surface epithelial cell damage induced by 20% ethanol in rats.
- Cytoprotective effects of NC-1300 and omeprazole on HClethanol-induced gastric lesions in rats.
- Effects of topical application of KT1-32 on transmucosal potential difference and acid secretion in the rat stomach.
- Effects of 16,16-dimethyl prostaglandin E2 on surface epithelial cell damage in the rat stomach induced by vagal nerve stimulation.
- The relationship of intraduodenal pH and delayed gastric emptying in duodenal ulceration induced by mepirizole or cysteamine in rats.
- Effects of MCI-727, a New Antiulcer Agent, on Various Gastric and Duodenal Lesions in Experimental Animals.
- Cytoprotective Action of L-Arginine against HCl-Induced Gastric Injury in Rats: Involvement of Nitric Oxide?
- Mechanisms Underlying Stimulation of Gastroduodenal HCO3- Secretion by NG-Nitro-L-Arginine Methyl Ester, an Inhibitor of Nitric Oxide Synthase, in Rats.
- Effects of KB-5492, 1-(3,4,5-trimethoxybenzyl)-4-((4-methoxyphenyl)oxycarbonylmethyl)piperazine monofumarate monohydrate, on gastric lesions and gastric secration in rats.
- Effects of a New Benzimidazole Derivative, NC-1300-O-3, on gastric Secretion and Gastroduodenal Lesions in Rats.
- Pathogenesis of the earliest epithelial cell damage induced by mepirizole and cysteamine in the rat duodenum.
- Histamine-induced villous damage in the rat duodenum.