Induction of CPP32-Like Activity and Inhibition of Interleukin 1β Converting Enzyme Activity in the Liver of a Mouse Concanavalin A-Induced Hepatitis Model
スポンサーリンク
概要
- 論文の詳細を見る
The objective of the present study was to determine the effects of concanavalin A (Con A) administration on the interleukin 1β converting enzyme (ICE) activity and CPP32-like activity in mouse liver. Treatment with Con A (0.2 mg/mouse, i.v.) caused an elevated plasma alanine aminotransferase (ALT) level at 8 hr after Con A injection. ICE activity was decreased at 8 and 24 hr after Con A treatment. In contrast, CPP32-like activity was increased at 24 hr after Con A injection. Since CPP32-like activity was induced after ALT had increased, the induction of CPP32-like activity may not be involved in Con A-induced hepatitis.
- 社団法人 日本薬理学会の論文
- 1998-07-01
著者
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Kobayashi Tadashi
Research Institute of Angiocardiology and Cardiovascular Clinic, Kyushu University
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Hara Kaoru
Research Laboratories Nippon Chemiphar Co. Ltd.
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OKAMOTO Toshihiro
Research Laboratories, Nippon Chemiphar Co., Ltd., Department of Experimental Pathology, Cancer Inst
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Okamoto Toshihiro
Research Laboratories Nippon Chemiphar Co. Ltd.
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TSUZUIKE Naoki
Zeria Pharmaceutical Co., Ltd.
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Tsuzuike Naoki
Zeria Pharmaceutical Co. Ltd.
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Kobayashi Tadashi
Research Laboratories Nippon Chemiphar Co. Ltd.
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OKAMOTO Tosihihiro
Research Laboratories, Nippon Chemiphar Co., Ltd.
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Kobayashi Tadashi
Research Institute Of Angiocardiology And Cardiovascular Clinic Kyushu University
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Okamoto Toshihiro
Research Laboratories Nippon Chemiphar Co. Ltd
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Kobayashi Tadashi
Research Laboratories, Nippon Chemiphar Co., Ltd.
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