Chronic Hepatitis in Interferon-γ Transgenic Mice Is Associated With Elevated CPP32-Like Activity and Interleukin-1β-Converting Enzyme Activity Suppression
スポンサーリンク
概要
- 論文の詳細を見る
Interferon-γ (IFN-γ) transgenic mice strongly express IFN-γ in the liver and develop chronic hepatitis. Furthermore, hepatocyte apoptosis was shown by the TdT-mediated dUTP-biotin nick endlabel- ing method. In the present study, interleukin-1β-converting enzyme (ICE) and CPP32-like protease activ- ities in the liver of IFN-γ transgenic mice were measured, using the synthetic substrates Ac-YVAD-MCA and Ac-DEVD-MCA. Plasma aspartate aminotransferase and alanine aminotransferase activities as well as CPP32-like activity were significantly elevated, while ICE activity was significantly reduced. The addition of the ICE inhibitor Ac-YVAD-CHO to IFN-γ transgenic mouse liver cell cytosol had no effect on the CPP32 activity, in contrast to a CPP32 inhibitor. The present results indicate that chronic hepatitis in the IFN-γ transgenic mouse is associated with a decrease in ICE and induction of CPP32-like activity.
- 社団法人 日本薬理学会の論文
- 1999-03-01
著者
-
HINO Okio
Department of Experimental Pathology, Cancer Institute
-
Hino Okio
Department Of Experimental Pathology Cancer Institute
-
Hara Kaoru
Research Laboratories Nippon Chemiphar Co. Ltd.
-
Nakano Yoshihisa
Research Laboratories Nippon Chemiphar Co. Ltd.
-
Yamamura Ken-ichi
Institute Of Molecular Embryology And Genetics Kumamoto University School Of Medicine
-
Yamamura Ken-ichi
Institute For Medical Genetics Kumamoto University Medical School
-
OKAMOTO Toshihiro
Research Laboratories, Nippon Chemiphar Co., Ltd., Department of Experimental Pathology, Cancer Inst
-
Okamoto Toshihiro
Research Laboratories Nippon Chemiphar Co. Ltd.
-
YAMAKAWA Tomio
Research Laboratories, Nippon Chemiphar Co., Ltd.
-
Yamakawa Tomio
Research Laboratories Nippon Chemiphar Co. Ltd.
-
Nakano Yoshihisa
Research Division For Development Of Anti-infective Agents Institute Of Development Aging And Cancer
-
Okamoto Toshihiro
Research Laboratories Nippon Chemiphar Co. Ltd
-
Okamoto Toshihiro
Research Laboratories, Nippon Chemiphar Co., Ltd.
関連論文
- Serum level of expressed in renal carcinoma (ERC)/ mesothelin in rats with mesothelial proliferative lesions induced by multi-wall carbon nanotube (MWCNT)
- Mutation analysis of the TSC1 and TSC2 genes in Japanese patients with pulmonary lymphangioleiomyomatosis
- A Novel "Nihon" Rat Model of a Mendelian Dominantly Inherited Renal Cell Carcinoma
- Malignant perivascular epithelioid cell tumor of the colon : Report of a case with molecular analysis
- RENAL CARCINOGENESIS : GENOTYPE, PHENOTYPE AND DRAMATYPE
- Renal carcinogenesis : Genotype, phenotype and dramatype
- Intragenic Tsc2 Somatic Mutations as Knudson's Second Hit in Spontaneous and Chemically Induced Renal Carcinomas in the Eker Rat Model
- PATHOPHYSIOLOGICAL FEATURES OF HEREDITARY CANCERS
- Cloning of the Rat Homologue of the von Hippel-Lindau Tumor Suppressor Gene and Its Non-somatic Mutation in Rat Renal Cell Carcinomas
- Allelic Loss at the Tuberous Sclerosis (Tsc2) Gene Locus in Spontaneous Uterine Leiomyosarcomas and Pituitary Adenomas in the Eker Rat Model
- Antitumor activity of anti-C-ERC/mesothelin monoclonal antibody in vivo
- Establishment of a novel specific ELISA system for rat N- and C-ERC/mesothelin. Rat ERC/mesothelin in the body fluids of mice bearing mesothelioma
- Novel ELISA system for detection of N-ERC/mesothelin in the sera of mesothelioma patients
- A Novel Gene"Niban "Upregulated in Renal Carcinogenesis: Cloning by the cDNA-amplified Fragment Length Polymorphism Approach
- Toward chemotherapy for Tsc2-mutant renal tumor
- Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-βgeo cassette
- Generation of Metastatic Variants of Eker Renal Carcinoma Cell Lines for Experimental Investigation of Renal Cancer Metastasis
- Age dependence of radiation-induced renal cell carcinomas in an Eker rat model
- A Novel Renal Carcinoma Predisposing Gene of the Nihon Rat Maps on Chromosome 10
- HZE Radiation Effects for Hereditary Renal Carcinomas
- Pathogenesis of multifocal micronodular pneumocyte hyperplasia and lymphangioleiomyomatosis in tuberous sclerosis and association with tuberous sclerosis genes TSC1 and TSC2
- Development of High-grade Renal Cell Carcinomas in Rats Independently of Somatic Mutations in the Tsc2 and VHL Tumor Suppressor Genes
- Knudson’s two hits, both associated with the insertions of genetic mobile elements in a rat pituitary adenoma
- JTII-1 A case of mesothelioma in which cytology was useful for the diagnosis
- CARCINOGENESIS IN TUBEROUS SCLEROSIS
- Diagnostic tumor marker of asbestos-related mesothelioma
- Hepatoprotective Drugs for the Treatment of Virus-Induced Chronic Hepatitis: From Hypercarcinogenic State to Hypocarcinogenic State
- Understanding the hypercarcinogenic state in chronic hepatitis: a clue to the prevention of human hepatocellular carcinoma
- Analysis of the initial gene in radiation induced tumors
- Down-regulation of cyclooxygenase-2 expression but up-regulation of cyclooxygenase-1 in renal carcinomas of the Eker (TSC2 gene mutant) rat model
- MOLECULAR BIOLOGY OF THE VHL GENE
- Molecular tumor markers for asbestos-related mesothelioma : Serum diagnostic markers
- Studies of familial tumors using models : genotype, phenotype, and dramatype in carcinogenesis
- Expression of Cyclooxygenase mRNA in the Livers of Mice With Interferon-γ Chronic Hepatitis
- Copy-Dependent and Position-Independent Expression of Rat Aldolase A Gene^1
- Comparative in vitro activity of carbapenem antibiotics against respiratory pathogens isolated in recent years
- In vitro antimicrobial activity and penetration rate into sputum of gatifloxacin , a novel 6-fluor0-8-methoxy quinolone, and its therapeutic efficacy in respiratory infections
- Chronic Hepatitis in Interferon-γ Transgenic Mice Is Associated With Elevated CPP32-Like Activity and Interleukin-1β-Converting Enzyme Activity Suppression
- Induction of Fas Ligand and Fas Antigen mRNA Expressions in Interferon-γ Transgenic Mouse Liver
- Induction of Tumor Necrosis Factor-α mRNA in the Kidney of the Mouse Chronic Hepatitis Model
- Induction of TNF-α gene expression in the liver of IFN-γ transgenic mouse
- Osteopontin expression in pulmonary tumor thrombotic microangiopathy caused by gastric carcinoma
- A 6-kb Upstream Region of the Huma Transthyretin Gene Can Direct Developmental, Tissue-Specific, and Quantitatively Normal Expression in Transgenic Mouse
- Establishment of novel mAb to human ERC/mesothelin useful for study and diagnosis of ERC/mesothelin-expressing cancers
- Influence of bone osteocalcin levels on bone loss induced by ovariectomy in rats
- Comparison of inhibitory effects of warfarin on γ-carboxylation between bone and liver in rats
- Effects of Vitamin K_2 (Menatetrenone) on Calcium Balance in Ovariectomized Rats
- Inhibitory Effect of Vitamin K_2 (Menatetrenone) on Bone Resorption in Ovariectomized Rats : A Histomorphometric and Dual Energy X-Ray Absorptiometric Study
- Effect of Gadolinium Chloride Treatment on Concanavalin A-Induced Cytokine mRNA Expression in Mouse Liver
- Effects of Concanavalin A Treatment on CD8 mRNA Expression in Mouse Liver
- Induction of CPP32-Like Activity and Inhibition of Interleukin 1β Converting Enzyme Activity in the Liver of a Mouse Concanavalin A-Induced Hepatitis Model
- Expression of Cytokine mRNA in Extrahepatic Organs in a Mouse Concanavalin A-Hepatitis Model
- The Protective Effect of Cyclosporine A on Anti-Fas Antibody-Induced Hepatitis in Mice
- Prevention of hereditary carcinogenesis
- Similarity of the secondary structure with identical seven bases in the pregenomic/genomic regions required for the replication of hepatitis B virus and hepatitis C virus
- Antibacterial effects of brand-name teicoplanin and generic products against clinical isolates of methicillin-resistant Staphylococcus aureus
- Establishment of an Efficient BAC Transgenesis Protocol and its Application to Functional Characterization of the Mouse Brachyury Locus
- Transgenic Mouse as Tools for the Study of Congenital Anomalies
- Relationship between the usage of carbapenem antibiotics and the incidence of imipenem-resistant Pseudomonas aeruginosa
- Antibacterial activity of carbapenems against clinical isolates of respiratory bacterial pathogens in the northeastern region of Japan in 2007
- DISSECTION OF MAMMALIAN DEVELOPMENT BY GENETIC APPROACHES
- Deficiency of the Erc/mesothelin gene ameliorates renal carcinogenesis in Tsc2 knockout mice
- Effects of Concanavalin A on Cytokine mRNA Expression in Mouse Liver
- 膵臓疾患におけるSPINK1の役割
- Effects of Immunosuppressants on Concanavalin A-Induced Interleukin-2 mRNA Expression in Mouse Liver
- The Roles of Serine Protease Inhibitor Kazal Type 1 (SPINK1) in Pancreatic Diseases
- A transgenic mouse model of familial amyloidotic polyneuropathy.
- HCV core protein promotes heparin binding EGF-like growth factor expression and activates Akt
- A 6-kb Upstream Region of the Human Transthyretin Gene Can Direct Developmental, Tissue-Specific, and Quantitatively Normal Expression in Transgenic Mouse.