Toward chemotherapy for Tsc2-mutant renal tumor
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概要
- 論文の詳細を見る
Recent genetic studies of Drosophila melanogaster and subsequent biochemical analysis in mammalian cells revealed that products of tuberous sclerosis genes, TSC1 and TSC2, regulate insulin signaling via suppression of p70 ribosomal S6 subunit-kinase (S6K) activity. In this study, using transplantation in the nude mouse, we found that the growth of a renal tumor cell line from Tsc2 knockout mouse was suppressed by the treatment of rapamycin, an inhibitor of mTOR (mammalian target of rapamycin) which is an upstream activator of S6K. The robust in vivo effect of rapamycin suggests that it can be used for chemotherapy of tuberous sclerosis-associated hamartomas and tumors. Other yet undiscovered chemicals selectively downregulate mTOR-S6K pathway may provide new therapeutic drugs for tuberous sclerosis.(Communicated by Takashi SUGIMURA, M. J. A., Jan. 14, 2003)
- 日本学士院の論文
著者
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HINO Okio
Department of Experimental Pathology, Cancer Institute
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Hino Okio
Department Of Experimental Pathology Cancer Institute
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ADACHI Hiroyuki
Department of Biotechnology, University of Tokyo
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Kobayashi Toshiyuki
Department of Pediatrics, Sapporo Medical University School of Medicine
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HIRAYAMA Youko
Department of Experimental Pathology, Cancer Institute
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MITANI Hiroaki
Department of Experimental Pathology, Cancer Institute
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Adachi Hiroyuki
Department Of Experimental Pathology Cancer Institute Japanese Foundation For Cancer Research
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Kobayashi Toshiyuki
Department Of Pediatrics Urakawa Redcross Hospital
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Adachi Hiroyuki
Department Of Biotechnology Graduate School Of Agricultural And Life Sciences University Of Tokyo
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Mitani Hiroaki
Department Of Experimental Pathology Cancer Institute Japanese Foundation For Cancer Research
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Mitani H
徳島大学医学部
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Kobayashi Toshiyuki
Department Of Pathology And Oncology Juntendo University School Of Medicine
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ADACHI Hiroyuki
Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research
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KOBAYASHI Toshiyuki
Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research
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HIRAYAMA Youko
Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research
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