Similarity of the secondary structure with identical seven bases in the pregenomic/genomic regions required for the replication of hepatitis B virus and hepatitis C virus
スポンサーリンク
概要
- 論文の詳細を見る
We described the existence of the similarity of the secondary structure in hepatitis B virus (HBV) packaging signal ε and in hepatitis C virus (HCV) 3X tail, both of which are considered to be important for the viral replication cycle. Seven nucleotide (nt) sequence (5-GGUGGCU-3) existed both in HBV ε nt 3169-3175 and HCV 3X tail nt 1-7. Furthermore, the 7-nt sequence paired with the 6-nt sequence (5-AGCCUC-3) of HBV ε(nt 3149-3154) and (5-AGCCCU-3) of HCV 3X tail (nt 15-20), to form the very similar secondary structure with one unpaired U. We consider the possibility that the common biological characters shared by these viruses are derived from the recognition of this conserved secondary structure by the viral or cellular proteins.
- 日本学士院の論文
著者
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HINO Okio
Department of Experimental Pathology, Cancer Institute
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Hino Okio
癌研究会癌研究所
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Hino Okio
Department Of Experimental Pathology Cancer Institute
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Hino O
Japanese Foundation Cancer Res. Tokyo
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KAJINO Kazunori
Department of Experimental Pathology, Cancer Institute
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Kajino Kazunori
Department Of Experimental Pathology Cancer Institute
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KAJINO Kazunori
Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research
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