Knudson’s two hits, both associated with the insertions of genetic mobile elements in a rat pituitary adenoma

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The Eker rat bears a germline mutation of the tumor suppressor Tsc2 gene with insertion of a retrotransposon, intracisternal A particle (IAP). With a second somatic mutation of the Tsc2 gene, virtually all Eker rats develop renal carcinoma. Furthermore, some of them develop pituitary adenomas which are also caused by a second hit mutation in the Tsc2 gene. Previously we found an Eker rat pituitary adenoma case with a rearranged Tsc2 gene by Southern blot analysis. In this study we determined its structure, and found that another retrotransposon, LINE1, was involved in the rearrangement of the wild type Tsc2 allele. To our knowledge, this is the first case of Knudson’s two hits associated with two retrotransposons.(Communicated by Masanori OTSUKA, M. J. A., April 14, 2003)
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