Expression of Cyclooxygenase mRNA in the Livers of Mice With Interferon-γ Chronic Hepatitis
スポンサーリンク
概要
- 論文の詳細を見る
Interferon−γ(IFN−γ)transgenic mice expressed the IFN−γ gene in the liver and developed chronic hepatitis.The expression of cyclooxygenase(Cox)−1 and −2 mRNA were studied in the livers of these mice.A faint band of Cox−1 mRNA was observed in the livers of both normal and transgenic mice.Slight expression of Cox−2 mRNA was observed in the normal mouse liver, and this mRNA expression was induced in the transgenic mouse liver.The present results showed the induction of Cox−2 mRNA expression in the livers of transgenic mice with chronic hepatitis.
- 社団法人 日本薬理学会の論文
- 2000-08-01
著者
-
HINO Okio
Department of Experimental Pathology, Cancer Institute
-
Hino Okio
日本ケミファ研究所
-
Hino Okio
Department Of Experimental Pathology Cancer Institute
-
OKAMOTO Toshihiro
Research Laboratories, Nippon Chemiphar Co., Ltd., Department of Experimental Pathology, Cancer Inst
-
YAMAMURA Kenichi
Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine
-
Okamoto T
Research Laboratories Nippon Chemiphar Co. Ltd
-
Okamoto Toshihiro
Research Laboratories Nippon Chemiphar Co. Ltd.
-
Yamamura Kenichi
Institute Of Molecular Embryology And Genetics Kumamoto University School Of Medicine
-
Okamoto Toshihiro
Research Laboratories Nippon Chemiphar Co. Ltd
関連論文
- Serum level of expressed in renal carcinoma (ERC)/ mesothelin in rats with mesothelial proliferative lesions induced by multi-wall carbon nanotube (MWCNT)
- Mutation analysis of the TSC1 and TSC2 genes in Japanese patients with pulmonary lymphangioleiomyomatosis
- A Novel "Nihon" Rat Model of a Mendelian Dominantly Inherited Renal Cell Carcinoma
- Malignant perivascular epithelioid cell tumor of the colon : Report of a case with molecular analysis
- RENAL CARCINOGENESIS : GENOTYPE, PHENOTYPE AND DRAMATYPE
- Renal carcinogenesis : Genotype, phenotype and dramatype
- Intragenic Tsc2 Somatic Mutations as Knudson's Second Hit in Spontaneous and Chemically Induced Renal Carcinomas in the Eker Rat Model
- PATHOPHYSIOLOGICAL FEATURES OF HEREDITARY CANCERS
- Cloning of the Rat Homologue of the von Hippel-Lindau Tumor Suppressor Gene and Its Non-somatic Mutation in Rat Renal Cell Carcinomas
- Allelic Loss at the Tuberous Sclerosis (Tsc2) Gene Locus in Spontaneous Uterine Leiomyosarcomas and Pituitary Adenomas in the Eker Rat Model
- Antitumor activity of anti-C-ERC/mesothelin monoclonal antibody in vivo
- Establishment of a novel specific ELISA system for rat N- and C-ERC/mesothelin. Rat ERC/mesothelin in the body fluids of mice bearing mesothelioma
- Novel ELISA system for detection of N-ERC/mesothelin in the sera of mesothelioma patients
- A Novel Gene"Niban "Upregulated in Renal Carcinogenesis: Cloning by the cDNA-amplified Fragment Length Polymorphism Approach
- Toward chemotherapy for Tsc2-mutant renal tumor
- Generation of Metastatic Variants of Eker Renal Carcinoma Cell Lines for Experimental Investigation of Renal Cancer Metastasis
- Age dependence of radiation-induced renal cell carcinomas in an Eker rat model
- A Novel Renal Carcinoma Predisposing Gene of the Nihon Rat Maps on Chromosome 10
- HZE Radiation Effects for Hereditary Renal Carcinomas
- Pathogenesis of multifocal micronodular pneumocyte hyperplasia and lymphangioleiomyomatosis in tuberous sclerosis and association with tuberous sclerosis genes TSC1 and TSC2
- Development of High-grade Renal Cell Carcinomas in Rats Independently of Somatic Mutations in the Tsc2 and VHL Tumor Suppressor Genes
- Knudson’s two hits, both associated with the insertions of genetic mobile elements in a rat pituitary adenoma
- JTII-1 A case of mesothelioma in which cytology was useful for the diagnosis
- CARCINOGENESIS IN TUBEROUS SCLEROSIS
- Diagnostic tumor marker of asbestos-related mesothelioma
- Hepatoprotective Drugs for the Treatment of Virus-Induced Chronic Hepatitis: From Hypercarcinogenic State to Hypocarcinogenic State
- Understanding the hypercarcinogenic state in chronic hepatitis: a clue to the prevention of human hepatocellular carcinoma
- Analysis of the initial gene in radiation induced tumors
- Down-regulation of cyclooxygenase-2 expression but up-regulation of cyclooxygenase-1 in renal carcinomas of the Eker (TSC2 gene mutant) rat model
- MOLECULAR BIOLOGY OF THE VHL GENE
- Molecular tumor markers for asbestos-related mesothelioma : Serum diagnostic markers
- Studies of familial tumors using models : genotype, phenotype, and dramatype in carcinogenesis
- Expression of Cyclooxygenase mRNA in the Livers of Mice With Interferon-γ Chronic Hepatitis
- Chronic Hepatitis in Interferon-γ Transgenic Mice Is Associated With Elevated CPP32-Like Activity and Interleukin-1β-Converting Enzyme Activity Suppression
- Induction of Fas Ligand and Fas Antigen mRNA Expressions in Interferon-γ Transgenic Mouse Liver
- Induction of Tumor Necrosis Factor-α mRNA in the Kidney of the Mouse Chronic Hepatitis Model
- Induction of TNF-α gene expression in the liver of IFN-γ transgenic mouse
- Osteopontin expression in pulmonary tumor thrombotic microangiopathy caused by gastric carcinoma
- Establishment of novel mAb to human ERC/mesothelin useful for study and diagnosis of ERC/mesothelin-expressing cancers
- Effect of Gadolinium Chloride Treatment on Concanavalin A-Induced Cytokine mRNA Expression in Mouse Liver
- Effects of Concanavalin A Treatment on CD8 mRNA Expression in Mouse Liver
- Induction of CPP32-Like Activity and Inhibition of Interleukin 1β Converting Enzyme Activity in the Liver of a Mouse Concanavalin A-Induced Hepatitis Model
- Expression of Cytokine mRNA in Extrahepatic Organs in a Mouse Concanavalin A-Hepatitis Model
- The Protective Effect of Cyclosporine A on Anti-Fas Antibody-Induced Hepatitis in Mice
- Prevention of hereditary carcinogenesis
- Similarity of the secondary structure with identical seven bases in the pregenomic/genomic regions required for the replication of hepatitis B virus and hepatitis C virus
- Deficiency of the Erc/mesothelin gene ameliorates renal carcinogenesis in Tsc2 knockout mice
- Effects of Concanavalin A on Cytokine mRNA Expression in Mouse Liver
- Effects of Immunosuppressants on Concanavalin A-Induced Interleukin-2 mRNA Expression in Mouse Liver
- HCV core protein promotes heparin binding EGF-like growth factor expression and activates Akt