Effects of Concanavalin A Treatment on CD8 mRNA Expression in Mouse Liver
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概要
- 論文の詳細を見る
The administration of concanavalin A (Con A) (0.2 mg/mouse) into mice induced significant elevation of plasma alanine aminotransferase (ALT) at 8.5 hr after Con A treatment. CD8 mRNA, which is a marker of cytotoxic T-cell, was strongly induced at 16 and 24 hr after Con A treatment. Although pretreatment with cyclosporine A (CsA) (50 and 100 mg/kg, i.p.) inhibited Con A-induced elevation of plasma ALT, it did not inhibit Con A-induced CD8 mRNA expression. Morphological study revealed lymphoid cell infiltration in the liver, but the lymphoid cells were not present at the site of hepatocyte necrosis. These results suggest that Con A-induced CD8+ T-cell infiltration has a minimal effect in the development of hepatitis.
- 社団法人 日本薬理学会の論文
著者
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Hara Kaoru
Research Laboratories Nippon Chemiphar Co. Ltd.
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Nakano Yoshihisa
Research Laboratories Nippon Chemiphar Co. Ltd.
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OKAMOTO Toshihiro
Research Laboratories, Nippon Chemiphar Co., Ltd., Department of Experimental Pathology, Cancer Inst
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Okamoto Toshihiro
Research Laboratories Nippon Chemiphar Co. Ltd.
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TSUZUIKE Naoki
Zeria Pharmaceutical Co., Ltd.
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Tsuzuike Naoki
Zeria Pharmaceutical Co. Ltd.
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Nakano Yoshihisa
Research Division For Development Of Anti-infective Agents Institute Of Development Aging And Cancer
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Okamoto Toshihiro
Research Laboratories Nippon Chemiphar Co. Ltd
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Okamoto Toshihiro
Research Laboratories, Nippon Chemiphar Co., Ltd.
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