Effects of Immunosuppressants on Concanavalin A-Induced Interleukin-2 mRNA Expression in Mouse Liver
スポンサーリンク
概要
- 論文の詳細を見る
Treatment of mice with concanavalin A (Con A) induced interleukin-2 (IL-2) mRNA expression in the liver, which might be a result of Con A-induced T-cell activation. Pretreatment with cyclosporine A (CsA) (50 mg/kg, i.p.) or dexamethasone (DEX) (2.5 mg/kg, i.p.) inhibited the Con A-induced liver injury, as assessed by the plasma alanine aminotransferase level, by 85% and 95%, respectively. CsA inhibited the Con A-induced IL-2 mRNA expression completely, whereas DEX only partially inhibited it. Thus CsA seems to prevent Con A-induced hepatitis mainly by inhibiting T-cell activation. In the case of DEX, rather than by inhibiting Con A-induced T-cell activation, it may prevent Con A-induced hepatitis through other means.
- 社団法人 日本薬理学会の論文
- 1998-07-01
著者
-
Okamoto Toshihiro
Research Laboratories Nippon Chemiphar Co. Ltd.
-
Kobayashi Tadashi
Research Laboratories Nippon Chemiphar Co. Ltd.
-
Kobayashi Tadashi
Research Institute Of Angiocardiology And Cardiovascular Clinic Kyushu University
-
Okamoto Toshihiro
Research Laboratories Nippon Chemiphar Co. Ltd
関連論文
- PATHOPHYSIOLOGY OF HISTAMINE-INDUCED CORONARY ARTERY SPASM : IN VITRO AND IN VIVO ANALYSIS OF REGIONAL CORONARY HYPERCONTRACTION : Blood Vessels : FREE COMMUNICATIONS (I) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCI
- Examination of Surface-Roughness of Silicon Crystals by Double-Crystal X-Ray Topography
- Hepatoprotective Drugs for the Treatment of Virus-Induced Chronic Hepatitis: From Hypercarcinogenic State to Hypocarcinogenic State
- Down-regulation of cyclooxygenase-2 expression but up-regulation of cyclooxygenase-1 in renal carcinomas of the Eker (TSC2 gene mutant) rat model
- Expression of Cyclooxygenase mRNA in the Livers of Mice With Interferon-γ Chronic Hepatitis
- Chronic Hepatitis in Interferon-γ Transgenic Mice Is Associated With Elevated CPP32-Like Activity and Interleukin-1β-Converting Enzyme Activity Suppression
- Induction of Fas Ligand and Fas Antigen mRNA Expressions in Interferon-γ Transgenic Mouse Liver
- Induction of Tumor Necrosis Factor-α mRNA in the Kidney of the Mouse Chronic Hepatitis Model
- Effect of Gadolinium Chloride Treatment on Concanavalin A-Induced Cytokine mRNA Expression in Mouse Liver
- Effects of Concanavalin A Treatment on CD8 mRNA Expression in Mouse Liver
- Induction of CPP32-Like Activity and Inhibition of Interleukin 1β Converting Enzyme Activity in the Liver of a Mouse Concanavalin A-Induced Hepatitis Model
- Expression of Cytokine mRNA in Extrahepatic Organs in a Mouse Concanavalin A-Hepatitis Model
- The Protective Effect of Cyclosporine A on Anti-Fas Antibody-Induced Hepatitis in Mice
- Inhibition of Concanavalin A-Induced Mice Hepatitis by Coumarin Derivatives
- Effects of Concanavalin A on Cytokine mRNA Expression in Mouse Liver
- Effects of Immunosuppressants on Concanavalin A-Induced Interleukin-2 mRNA Expression in Mouse Liver