Effect of Gadolinium Chloride Treatment on Concanavalin A-Induced Cytokine mRNA Expression in Mouse Liver
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概要
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The effect of Kupffer cell depression on concanavalin A (Con A)-induced cytokine mRNA expression in the liver was studied. Gadolinium chloride (GdCl3) is a commonly used Kupffer cell inhibitor. GdCl3 (40 mg/kg, i.p.) was injected into each mouse, and 24 hr later, Con A (0.2 mg/mouse) was administered. Plasma was obtained at 24 hr after Con A treatment for alanine aminotransferase (ALT) measurement. GdCl3 treatment inhibited Con A-induced elevation of ALT. However, it did not inhibit Con A-induced interleukin-2 or tumor necrosis factor-α mRNA expression. The present results suggest that Kupffer cells are not responsible for Con A-induced cytokine expression in the liver.
- 社団法人 日本薬理学会の論文
著者
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Hara Kaoru
Research Laboratories Nippon Chemiphar Co. Ltd.
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OKAMOTO Toshihiro
Research Laboratories, Nippon Chemiphar Co., Ltd., Department of Experimental Pathology, Cancer Inst
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Okamoto Toshihiro
Research Laboratories Nippon Chemiphar Co. Ltd.
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MAEDA Osamu
Research Laboratories, Nippon Chemiphar Co., Ltd.
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TSUZUIKE Naoki
Zeria Pharmaceutical Co., Ltd.
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Tsuzuike Naoki
Zeria Pharmaceutical Co. Ltd.
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Maeda Osamu
Research Laboratories Nippon Chemiphar Co. Ltd.
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Okamoto Toshihiro
Research Laboratories Nippon Chemiphar Co. Ltd
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Okamoto Toshihiro
Research Laboratories, Nippon Chemiphar Co., Ltd.
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