The Protective Effect of Cyclosporine A on Anti-Fas Antibody-Induced Hepatitis in Mice
スポンサーリンク
概要
- 論文の詳細を見る
The effect of cyclosporine A (CsA) on anti-Fas antibody-induced hepatitis was studied. The administration of anti-Fas antibody (250 μg/kg) to mice elevated plasma alanine aminotransferase (ALT) activity at 3 hr. This anti-Fas antibody-induced elevation of ALT was inhibited by treatment with CsA (10, 30 and 100 mg/kg) in a dose-dependent manner. Anti-Fas antibody administration elevated CPP32-like protease activity at 3 hr in mouse liver, and this elevation of CPP32-like activity was inhibited by treatment with CsA. The present results show that CsA treatment inhibits the anti-Fas antibody-induced apoptotic process of hepatitis, at least in part, by affecting a reaction upstream of CPP32-like protease activation.
- 社団法人 日本薬理学会の論文
- 1999-04-01
著者
-
OKAMOTO Toshihiro
Research Laboratories, Nippon Chemiphar Co., Ltd., Department of Experimental Pathology, Cancer Inst
-
HARA Atsuko
Research Laboratories, Nippon Chemiphar Co., Ltd.
-
Hara Atsuko
Research Laboratories Nippon Chemiphar Co. Ltd.
-
Okamoto Toshihiro
Research Laboratories Nippon Chemiphar Co. Ltd.
-
HITOMI Yuji
Zeria Pharmaceutical Co.,Ltd.
-
Hitomi Yuji
Zeria Pharmaceutical Co. Ltd.
-
Okamoto Toshihiro
Research Laboratories Nippon Chemiphar Co. Ltd
関連論文
- Hepatoprotective Drugs for the Treatment of Virus-Induced Chronic Hepatitis: From Hypercarcinogenic State to Hypocarcinogenic State
- Down-regulation of cyclooxygenase-2 expression but up-regulation of cyclooxygenase-1 in renal carcinomas of the Eker (TSC2 gene mutant) rat model
- Expression of Cyclooxygenase mRNA in the Livers of Mice With Interferon-γ Chronic Hepatitis
- Chronic Hepatitis in Interferon-γ Transgenic Mice Is Associated With Elevated CPP32-Like Activity and Interleukin-1β-Converting Enzyme Activity Suppression
- Induction of Fas Ligand and Fas Antigen mRNA Expressions in Interferon-γ Transgenic Mouse Liver
- Induction of Tumor Necrosis Factor-α mRNA in the Kidney of the Mouse Chronic Hepatitis Model
- Effect of Gadolinium Chloride Treatment on Concanavalin A-Induced Cytokine mRNA Expression in Mouse Liver
- Effects of Concanavalin A Treatment on CD8 mRNA Expression in Mouse Liver
- Induction of CPP32-Like Activity and Inhibition of Interleukin 1β Converting Enzyme Activity in the Liver of a Mouse Concanavalin A-Induced Hepatitis Model
- Expression of Cytokine mRNA in Extrahepatic Organs in a Mouse Concanavalin A-Hepatitis Model
- The Protective Effect of Cyclosporine A on Anti-Fas Antibody-Induced Hepatitis in Mice
- Effects of Concanavalin A on Cytokine mRNA Expression in Mouse Liver
- Effects of Immunosuppressants on Concanavalin A-Induced Interleukin-2 mRNA Expression in Mouse Liver