Induction of Fas Ligand and Fas Antigen mRNA Expressions in Interferon-γ Transgenic Mouse Liver
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概要
- 論文の詳細を見る
The interferon-γ (IFN-γ) transgenic mouse develops chronic hepatitis. In the present study, lymphoid cell infiltration and expression of the Fas system were studied in the transgenic mouse liver. Morphological analysis showed the infiltration of lymphoid cells at the portal area and necro-inflammation piecemeal necrosis and the intralobular region. The polymerase chain reaction revealed induction of Fas antigen and Fas ligand mRNA expressions. The chronic hepatitis in this mouse reflects the profiles of human chronic hepatitis.
- 社団法人 日本薬理学会の論文
- 1998-10-01
著者
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HINO Okio
Department of Experimental Pathology, Cancer Institute
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Hino Okio
Department Of Experimental Pathology Cancer Institute
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Yamamura Ken-ichi
Institute Of Molecular Embryology And Genetics Kumamoto University School Of Medicine
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Yamamura Ken-ichi
Institute For Medical Genetics Kumamoto University Medical School
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OKAMOTO Toshihiro
Research Laboratories, Nippon Chemiphar Co., Ltd., Department of Experimental Pathology, Cancer Inst
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Okamoto Toshihiro
Research Laboratories Nippon Chemiphar Co. Ltd.
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YAMAKAWA Tomio
Research Laboratories, Nippon Chemiphar Co., Ltd.
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Yamakawa Tomio
Research Laboratories Nippon Chemiphar Co. Ltd.
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Okamoto Toshihiro
Research Laboratories Nippon Chemiphar Co. Ltd
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Okamoto Toshihiro
Research Laboratories, Nippon Chemiphar Co., Ltd.
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