Effects of Vitamin K_2 (Menatetrenone) on Calcium Balance in Ovariectomized Rats
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概要
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Vitamin K2 (menatetrenone) has been used for the treatment of osteoporosis in Japan. We investigated the effects of ovariectomy (OVX) and vitamin K2 on the calcium (Ca) balance in 20-week-old female Fischer rats. Vitamin K2 (31 mg/kg per day) was given to animals as a dietary supplement. At weeks 4 and 8 after OVX, a Ca balance study was performed for 5 days. The intestinal Ca transport was determined using the everted gut-sac technique at week 9. The Ca balance was poorer in the OVX-control group than in the sham-control group at weeks 4 and 8 after OVX. The Ca balance improved significantly in the vitamin K2 groups as compared with the sham- and OVX-control groups. The intestinal Ca transport decreased due to OVX and was higher in the vitamin K2 administration groups than in the sham- and OVX-control groups, but not to a significant extent. The bone mineral density in the femoral metaphysis as well as the cortical area and cortical thickness in the femoral diaphysis in the OVX-control group were lower than in the sham-control group. The administration of vitamin K2 significantly inhibited an OVX-induced decrease in cortical area and cortical thickness in the femur. These findings suggest that the poor Ca balance observed in ovariectomized rats may be improved by vitamin K2; vitamin K2 may be involved in preventing bone loss in vivo.
- 社団法人 日本薬理学会の論文
- 2002-01-01
著者
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KOBAYASHI Masatoshi
Department of Anatomy (2), Kurume University School of Medicine
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Kobayashi Mikako
東京家政大学 院
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Kobayashi M
Department Of Health Science International University Of Health And Welfare
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Hara Kaoru
Research Laboratories Nippon Chemiphar Co. Ltd.
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Kobayashi Masatoshi
Pharmacological Evaluation Applied Drug Research Department Clinical Research Center Eisai Co. Ltd.
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Kobayashi Masatoshi
Department Of Anatomy & Histology Kurume University School Of Medicine
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Hara Kunio
Department Of Environmental Medicine School Of Medicine Kurume University
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HARA Kuniko
Department of Applied Drug Research, Pharmacological Evaluation Section, Clinical Research Center, E
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AKIYAMA Yasuhiro
Department of Applied Drug Research, Pharmacological Evaluation Section, Clinical Research Center, E
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Akiyama Yasuhiro
Pharmacological Evaluation, Applied Drug Research Department, Clinical Research Center, Eisai Co., Ltd.
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Akiyama Yasuhiro
Department of Applied Drug Research, Eisai Co., Ltd.
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