A Peroxisome Proliferator-Activated Receptor γ Agonist Influenced Daily Profile of Energy Expenditure in Genetically Obese Diabetic Rats
スポンサーリンク
概要
- 論文の詳細を見る
Otsuka Long Evans Tokushima Fatty (OLETF) rats were developed as a model of non-insulin-dependent diabetes mellitus (NIDDM) with mild obesity. We reported that the daily profiles of energy expenditure associated with two peaks (one between 05:00 and 08:00 and the other between 20:00 and 22:00) were observed at 8 weeks of age (without NIDDM), while these two peaks disappeared at 24 weeks of age with NIDDM. As a new anti-diabetic drug, a peroxisome proliferator-activated receptor γ agonist pioglitazone hydrochloride has been developed, we examined whether pioglitazone normalized daily profiles of energy expenditure at 24 weeks of age. A control diet and pioglitazone (0.1%)-containing diet were fed from 6 weeks of age. The two peaks of daily profiles of energy expenditure, which disappeared in OLETF rats with the control diet at 24 weeks of age, were reproduced by administration of pioglitazone. The respiratory quotient was lower and fat derived energy used for combustion was increased by pioglitazone at both ages. The body weight, daily food intake, plasma levels of fat, insulin, leptin and the wet weight of visceral fat were not influenced, but the levels of blood hemoglobin A1c and plasma tumor necrosis factor α were decreased by pioglitazone. Administration of pioglitazone improved daily profiles of energy expenditure via affecting glucose and fat metabolisms.
- 社団法人 日本薬理学会の論文
- 2002-03-01
著者
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YOSHIDA Yuki
Department of Neurosurgery, Iwate Medical University
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FUNAKOSHI Akihiro
Department of Gastroenterology, National Kyushu Cancer Center
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KOBAYASHI Mikako
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokka
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Kobayashi Mikako
東京家政大学 院
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Kobayashi M
Department Of Health Science International University Of Health And Welfare
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Kobayashi Mikako
Department Of Clinical Nutrition Faculty Of Home Economics Tokyo-kasei University
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Ohta Minoru
Department Of Clinical Physiology Tokyo Metropolitan Institute Of Gerontology
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KANAI Setsuko
Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology
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MIYASAKA Kyoko
Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology
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ICHIKAWA Mineko
Department of Nutrition, Tokyo Metropolitan Institute of Gerontology
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ICHIMARU Yuhei
Department of Clinical Nutrition, Tokyo Kasei University
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SHIMAZOE Takao
The Department of Pharmacology, Graduate School of Pharmaceutical Science, Kyushu University
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WATANABE Shigenori
The Department of Pharmacology, Graduate School of Pharmaceutical Science, Kyushu University
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Shimazoe T
Kyushyu Univ. Fukuoka Jpn
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Shimazoe Takao
東京都老人総合研究所
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Shimazoe Takao
Department Of Clinical Physiology Tokyo Metropolitan Institute Of Gerontology
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Ichimaru Yuhei
東京家政大学 院
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Ichimaru Yuhei
Department Of Clinical Nutrition Tokyo Kasei University
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Miyasaka Kyoko
Department Of Clinical Physiology Tokyo Metropolitan Institute Of Gerontology
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Kanai Setsuko
Department Of Clinical Physiology Tokyo Metropolitan Institute Of Gerontology
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Miyahara K
Department Of Molecular Biotechnology Faculty Of Engineering Hiroshima University
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Funakoshi A
National Kyushu Cancer Center Fukuoka Jpn
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Ichikawa M
Department Of Nutrition Tokyo Metropolitan Institute Of Gerontology
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Ichikawa Mineko
Department Of Clinical Physiology Tokyo Metropolitan Institute Of Gerontology
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Shimazoe Takao
The Department Of Pharmacology Graduate School Of Pharmaceutical Science Kyushu University
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Funakoshi Akihiro
Department Of Digestive Diseases National Kyushu Cancer Center
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Takiguchi Soichi
Division Of Clinical Research National Kyushu Cancer Center
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Kobayashi Masatoshi
Pharmacological Evaluation Applied Drug Research Department Clinical Research Center Eisai Co. Ltd.
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Yoshida Yuki
Department Of Cardio-angiology Kitasato University School Of Medicine
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Yoshida Yuki
Department Of Clinical Physiology Tokyo Metropolitan Institute Of Gerontology
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Ichimaru Yuhei
Department Of Bioclimatology And Medicine Research Institute Of Balneotherapeutics Kyushu University
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Ohta M
Department Of Clinical Physiology Tokyo Metropolitan Institute Of Gerontology
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Watanabe S
Kyushu Univ. Fukuoka Jpn
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Yoshida Yuki
Department Of Bioscience Tokyo University Of Agriculture
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Ohta Minoru
Department Of Animal Science Faculty Of Agriculture Tohoku University
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Funakoshi Akihiro
The Department Of Gastroenterology National Kyushu Cancer Center
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