Lowered Entrainment Function in the Suprachiasmatic Nucleus of Otsuka Long Evans Tokushima Fatty (OLETF) Rats
スポンサーリンク
概要
- 論文の詳細を見る
The entrainment function in the suprachiasmatic nucleus (SCN) of young non-diabetic Otsuka Long Evans Tokushima Fatty (OLETF) rats was studied. OLETF rats significantly needed more days for re-entrainment to a new light-dark cycle than control Long Evans Tokushima Otsuka (LETO) rats. We also assessed Fos expression in the SCN induced by dim light exposure. The number of Fos-immunoreactive cells was significantly decreased in 5- to 13-week-old OLETF rats compared with LETO rats. Moreover, the effect of glutamate on neuronal activity in the SCN of OLETF rats were investigated. In young non-diabetic OLETF rats, the phase delay in the SCN neuronal firing rhythm induced by 1 μM glutamate was significantly less than that in LETO rats. These results suggested that the entrainment function is reduced in OLETF rats before the onset of diabetes.
- 社団法人 日本薬理学会の論文
- 1999-05-01
著者
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MIYASAKA Kyoko
Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology
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KONO Akira
Division of Chemotherapy, National Kyushu Cancer Center
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WATANABE Shigenori
The Department of Pharmacology, Graduate School of Pharmaceutical Science, Kyushu University
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Shimazoe T
Kyushyu Univ. Fukuoka Jpn
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Shimazoe Takao
東京都老人総合研究所
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Shimazoe Takao
Department Of Clinical Physiology Tokyo Metropolitan Institute Of Gerontology
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Kono Akira
National Kyushu Cancer Center
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Kono A
National Kyushu Cancer Center Fukuoka Jpn
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Miyasaka Kyoko
Department Of Clinical Physiology Tokyo Metropolitan Institute Of Gerontology
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NAKAMURA Sachiko
Department of Obstetrics and Gynecology, Faculty of Medicine, Kagoshima University
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FUNAKOSHI AKIHIRO
National Kyushu Cancer Center
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Funakoshi A
National Kyushu Cancer Center Fukuoka Jpn
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Funakoshi Akihiro
National Epilepsy Center Shizuoka Medical Institute Of Neurological Disorders
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MAETANI Miyuki
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University
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WATANABE Shigenori
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University
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Maetani Miyuki
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyushu University
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Shimazoe Takao
The Department Of Pharmacology Graduate School Of Pharmaceutical Science Kyushu University
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Funakoshi Akihiro
Department Of Digestive Diseases National Kyushu Cancer Center
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YAMANOUCHI Shiro
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University
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Nakamura Sachiko
Department Of Obstetrics And Gynecology Faculty Of Medicine Kagoshima University
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Takiguchi Soichi
Division Of Clinical Research National Kyushu Cancer Center
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Yamanouchi Shiro
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyushu University
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Watanabe S
Kyushu Univ. Fukuoka Jpn
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Watanabe Shigenori
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyushu University
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Nakamura Sachiko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyushu University
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Nakamura Sachiko
Department Of Materials Science And Technology Faculty Of Science And Technology Hirosaki University
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Funakoshi Akihiro
The Department Of Gastroenterology National Kyushu Cancer Center
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Nakamura Sachiko
Department of Marine Science and Resources, College of Bioresource Sciences, Nihon University
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Nakamura Sachiko
Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences
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