Detrimental Role of Corticotropin-Releasing Factor on the Decrease of CA1 Field Potential Induced by In Vitro Ischemia in Rat Hippocampal Slices
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概要
- 論文の詳細を見る
This experiment was designed to test the hypothesis that endogenous corticotropin-releasing factor (CRF) contributes to the neurodegenerative process following an ischemic insult. To test this hypothesis, the effects of chronic intracerebroventricular administration of CRF or astressin, a CRF-receptor antagonist, on the decrease in the Schaffer collateral-CA1 field potential induced by hypoxia/hypoglycemia (ischemia), were tested in rat hippocampal slices. The chronic treatment with CRF had a significant exacerbating effect on the 10-min ischemia, a condition that did not affect the evoked synaptic response in the hippocampal CA1 area, as compared to vehicle-treated rats. On the other hand, astressin had a significant ameliorative effect on the 15-min ischemia-induced reduction of the evoked synaptic response in the hippocampal CA1 area. These findings suggest that CRF accelerates hippocampal ischemic vulnerability induced by hypoxia and hypoglycemia.
- 社団法人 日本薬理学会の論文
- 2004-01-01
著者
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YAMAMOTO Tsuneyuki
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University
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WATANABE Shigenori
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University
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Yamamoto Tsuneyuki
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyushu University
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KAGAMIISHI Yoshifumi
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University
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Kagamiishi Yoshifumi
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyushu University
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Yamamoto Tsuneyuki
Department Of Developmental Biology Of Hard Tissue Graduate School Of Dental Medicine Hokkaido Unive
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Watanabe Shigenori
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyushu University
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Watanabe Shigenori
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyushu University
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