Inhibitory Effect of NMDA on Dopaminergic Transmission in a Slice Preparation of Rat Globus Pallidus.
スポンサーリンク
概要
- 論文の詳細を見る
The effect of <I>N</I>-methyl-D-aspartate (NMDA) on KCl-evoked endogenous dopamine (DA) release from slices of rat globus pallidus (GP) was examined. NMDA inhibited the KCl-evoked DA release in a dose-dependent manner. This in hibition was blocked by CPP, an NMDA antagonist. Tetrodotoxin partially antagonized the effect of NMDA. The NMDA-induced inhibition was also partially antagonized by bicuculline methiodide and was mimicked by muscimol. These results strongly suggest that 1) an activation of NMDA receptors exerts an inhibitory effect on dopaminergic transmission in GP and 2) GABAergic transmission is involved in the effect of NMDA.
- 公益社団法人 日本薬理学会の論文
著者
-
Koizumi Shuichi
Department Of Urology Shiga University Of Medical Science
-
Kataoka Yasufumi
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
-
Watanabe Shigenori
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyushu University
-
Yamamoto Kenji
Department Of Cardiovascular Surgery Kanagawa Cardiovascular And Respiratory Center
-
Nakanishi Hiroshi
Department of Applied Physics, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan
-
Yamamoto Kenji
Department of Pharmacology, Faculty of Dentistry, Kyushu University
-
Shindou Tomomi
Department of Pharmacology, Faculty of Dentistry, Kyushu University
-
Koizumi Shuichi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University
関連論文
- Novel Surface Processing with Sulfonic Acid for Quantum Dot and Its Characteristics
- On the Cyto-Toxicity Caused by Quantum Dots
- Altered Expression of γ-Glutamylcysteine Synthetase, Metallothionein and Topoisomerase I or II during Acquisition of Drug Resistance to Cisplatin in Human Ovarian Cancer Cells
- Postnatal Blocking of Interferon-γ Function Prevented Atherosclerotic Plaque Formation in Apolipoprotein E-Knockout Mice
- Forced Exercise-Induced Flushing of Tail Skin in Ovariectomized Mice, as a New Experimental Model of Menopausal Hot Flushes
- No evidence for significant association between GABA receptor genes in chromosome 15q11-q13 and autism in a Japanese population
- Tachykinin 1 (TAC1) gene SNPs and haplotypes with autism : A case-control study
- Serotonin transporter gene promoter polymorphism and autism : A family-based genetic association study in Japanese population
- No association of FOXP2 and PTPRZ1 on 7q31 with autism from the Japanese population
- Cyclic AMP Phosphodiesterase 4 Isoenzyme Inhibitory Activity of (R)- and (S)-Isomer of 7-Methyl- or 8-Alkyl-4, 5, 7, 8-tetrahydroimidazo [2,1-i] -purin-5-one (Highlihted paper slected by Editor-in-chief)(Medicinal Chemistry)
- Synthesis and Cyclic AMP Phosphodiesterase 4 Isoenzyme Inhibitory Activity of Heterocycle Condensed Purines
- Phosphodiesterase 4 Isoenzyme Inhibitory Activity of 3-Phenylxanthines and 4-Phenyl[i]condensed-purines
- Condensed-Purines Syntheses of Tetrahydro-1,4-diazepino[1,2,3-gh]purin-2-one and Hexahydro-1,4-diazocino[1,2,3-gh]purin-2-one
- Structural Analysis of Disaccharides Synthesized by β-D-Glucosidase of Bifidobacterium breve clb and Their Assimilation by Bifidobacteria
- Transglycosylation Activity of β-N-Acetylhexosaminidase from Penixillium pxalicum and Its Application to Synthesis of a Drug Carrier
- Analysis of Low Temperature Inducible Mechanism of γ-Glutamyltranspeptidase of Escherichia coli K-12
- Cloning and Nucleotide Sequence of the β-D-Glucosidase Gene from Bifidobacterium breve clb, and Expression of β-D-Glucosidase Activity in Escherichia coli
- Mapping, Cloning, and DNA Sequencing of pepB Which Encodes Peptidase B of Escherichia coli K-12
- Screening for Bacterial Strains Producing Lactate Oxidase
- Transcriptional Regulation of Tyrosine Phenol-Lyase Gene of Erwinia herbicola AJ2985
- Subunit Association of γ-Glutamyltranspeptidase of Escherichia coli K-12^1
- Formation of Lyso-glycosphingolipids by Streptomyces sp.
- Effect of Site-Directed Mutations on Processing and Activity of γ-Glutamyltranspeptidase of Escherichia coli K-12
- OJ-255 A Possible Role of Periodontitis in Acute Myocardial Infarction(Acute myocardial infarction, clinical (pathophysiology)-2 (IHD) OJ43,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Characterization of New Fluorogenic Substrates for the Rapid and Sensitive Assay of Cathepsin E and Cathepsin D^1
- Deglycosylated Glucoamylase from Rhizopus niveus is Precipitated by Flavobacterium sp. Endo-β-N-acetylglucosaminidase(Microbiology & Fermentation Industry)
- Angiostatin : An Endogenous Inhibitor of Angiogenesis and Tumor Growth
- Thallium-201 brain SPECT to diagnose aggressiveness of meningiomas
- Differential diagnosis in patients with ring-like thallium-201 uptake in brain SPECT
- Biofeedback Training for Bronchial Asthma (Part I)
- Expression of the β-D-Glucosidase I Gene in Bifidobacterium breve 203 during Acclimation to Cellobiose
- Unique Production of a Disaccharide, Galβ1→3GalNAc, by Endo-α-N-Acetylgalactosaminidase of Alcaligenes sp.
- Preservation of Raw Fish and Meat(Food & Nutrition)
- Peptide Production from Protein without Salt(Microbiology & Fermentation Industry)
- Induction and Efficient Purification of Endo-α-N-acetylgalactosaminidase from Alcaligenes sp.(Microbiology & Fermentation Industry)
- Isolation and Characterization of a Blood Group A Substancedegrading α-N-Acetylgalactosaminidase from an Acremonium sp.
- A Novel End-β-N-acetylglucosaminidase Acting on Complex Oligosaccharides of Glycoproteins in a Fungus (Microbiological Fermentation Industry)
- Effect of Yeast Extract on Endo-β-N-acetylglucosaminidase Production by a Flavobacterium sp.(Microbiology & Fermentation Industry)
- Purification, Characterization, and Sequencing of Two Cysteine Proteinase Inhibitors, Sca and Scb, from Sunflower (Helianthus annuus) Seeds
- Characterization of Phagosomal Subpopulations along Endocytic Routes in Osteoclasts and Macrophages
- An Effect of Appreciating Music on Emotion : Follow Up of the Profile of Mood States Score Before and After Appreciating Music
- The treatment of neuroleptic malignant syndrome using dantrolene sodium
- Biofeedback Training for Bronchial Asthma (Part II)
- On the Trend of Biofeedback Studies as seen in CIM
- Entrainment Function in the Suprachiasmatic Nucleus of Streptozotocin-Induced Diabetic Rats
- Neuroprotective Effect of TTC-909, an Isocarbacyclin Methyl Ester Incorporated in Lipid Microspheres, on Hippocampal Delayed Neuronal Death of Stroke-Prone Spontaneously Hypertensive Rats
- Histologicak Evience for Neuroprotective Action of Nebracetam on Ischemic Neuronal Injury in the Hippocampus of Stroke-Prone Spontaneously Hypertensive Rats
- An Involvement of Granulocyte Medullasin in Phenytoin-Induced Gingival Overgrowth in Rats
- Effects of localized lesions in the lateral suprasylvian cortex on convergence eye movement in cats
- The Regulation of Bone Resorption in Tooth Formation and Eruption Processes in Mouse Alveolar Crest Devoid of Cathepsin K
- Gingipains Inactivate a Cell Surface Ligand on Porphyromonas gingivalis That Induces TLR2- and TLR4-Independent Signaling
- Determination of salicylic acid in human serum with capillary zone electrophoresis
- Menkes' Kinky Hair Disease Associated with a Large Bladder Diverticulum: A Case Report
- Time-Dependent Effect of Glutamate on Long-Term Potentiation in the Suprachiasmatic Nucleus of Rats
- Both Metabotropic Glutamate I and II Receptors Mediate Augmentation of Dopamine Release From the Striatum in Methamphetamine-Sensitized Rats
- Effects of Adenosine A_1- and A_-Receptor Agonists on Enhancement of Dopamine Release From the Striatum in Methamphetamine-Sensitized Rats
- Repeated Adenosine Pre-treatment Potentiates the Acute Effect of Methamphetamine in Rats
- Vulnerability of Synaptic Plasticity in the Striatum of Methamphetamine-Sensitized Rats
- Methamphetamine : Induced Sensitization of Dopamine Release via a Metabotropic Glutamate Receptor Mediated Pathway in Rat Striatal Slices
- Rapid Degradation of Cathepsin E in Pre-Golgi Compartments after Tunicamycin Treatment
- Different Effects of Trypsin Inhibitors on Intestinal Gene Expression of Secretin and on Pancreatic Bicarbonate Secretion in CCK-A-Receptor-Deficient Rats
- Lowered Entrainment Function in the Suprachiasmatic Nucleus of Otsuka Long Evans Tokushima Fatty (OLETF) Rats
- Particulate Matter Analyses after Dissolution of Powder Antibiotic Injections Used in the Pediatric Ward
- Detrimental Role of Corticotropin-Releasing Factor on the Decrease of CA1 Field Potential Induced by In Vitro Ischemia in Rat Hippocampal Slices
- Soybean Isoflavones Eliminate Nifedipine-Induced Flushing of Tail Skin in Ovariectomized Mice
- PHARMACOLOGICAL CHARACTERISTICS OF ABNORMAL BEHAVIOR INDUCED BY HARMINE WITH SPECIAL REFERENCE TO TREMOR IN MICE
- Protective Action of Indapamide, a Thiazide-Like Diuretic, on Ischemia-Induced Injury and Barrier Dysfunction in Mouse Brain Microvascular Endothelial Cells
- Application of high-performance thin-layer chromatography for the detection of organophosphorus insecticides in human serum after acute poisoning
- Micellar electrokinetic capillary chromatography for therapeutic drug monitoring of zonisamide
- Enhancement by Morphine of Radiographic Contrast Media-Induced Histamine Release in Rat Peritoneal Mast Cells
- Inhibitory Action of Nebracetam on Various Stimulti-Evoked Increases in Intracellular Ca^ Concentrations in Cultured Rat Cerebellar Granule Cells
- A Key Role of the Mammillary Body in Mediation of the Antianxiety Action of Zopiclone, a Cyclopyrrolone Derivative
- THE EFFECT OF AGE ON THE DEVELOPMENT OF HYPEREMOTIONALITY FOLLOWING BILATERAL OLFACTORY BULBECTOMY IN RATS
- THE ROLE OF NORADRENERGIC AND SEROTONERGIC SYSTEMS IN THE HIPPOCAMPAL KINDLING EFFECT
- EFFECTS OF RESERPINE, α-METHYL-p-TYROSINE, P-CHLOROPHENYLALANINE AND 5, 7-DIHYDROXYTRYPTAMINE ON THE HIPPOCAMPAL KINDLING EFFECT IN RATS
- Structural Optimization of the Antimicrobial Peptide Agent Omigard^ by Increasing its Activity as a Surfactant and the α-Helical Structure Ratio
- EFFECTS OF DELTA-9-TETRAHYDROCANNABINOL ON THE CARDIOVASCULAR SYSTEM, AND PRESSOR AND BEHAVIORAL RESPONSES TO BRAIN STIMULATION IN RATS
- EFFECTS OF PSYCHOTROPIC DRUGS INJECTED INTO THE LIMBIC STRUCTURES ON MOUSE-KILLING BEHAVIOR IN THE RAT WITH OLFACTORY BULB ABLATIONS
- EFFECTS OF ELECTROCONVULSIVE SHOCK ON MOUSE-KILLING BEHAVIOR (MURICIDE) IN OLFACTORY BULBECTOMIZED RATS
- EFFECT OF STIMULATION OF LOCUS COERULEUS ON THE EVOKED POTENTIAL IN THE AMYGDALA IN RATS
- THE EMOTIONAL COMMUNICATION BASED ON METHAMPHETAMINE MORTALITY AS THE INDEX IN OLFACTORY BULBECTOMIZED MICE
- INFLUENCE OF AGGREGATION ON THE ACTION OF METHAMPHETAMINE IN LOCOMOTOR ACTIVITY
- CHANGES IN SENSITIVITY OF MICE TO ANTICONVULSANT DRUGS FOLLOWING BILATERAL OLFACTORY BULB ABLATIONS
- EFFECTS OF MONOAMINES INJECTED INTO THE HIPPOCAMPUS ON HIPPOCAMPAL SEIZURE DISCHARGES IN THE RABBIT
- EFFECT OF MEDIAN RAPHE STIMULATION ON HIPPOCAMPAL SEIZURE DISCHARGE INDUCED BY CARBACHOL IN THE RABBIT
- Estrogen deficiency impairs sensitivity of the baroreceptor reflex and vasomotor functions in the aorta
- Tumor Necrosis Factor-α Mediates the Blood-Brain Barrier Dysfunction Induced by Activated Microglia in Mouse Brain Microvascular Endothelial Cells
- Effects of MPC-1304, a Novel Calcium Antagonist, on Stroke-Prone Spontaneously Hypertensive Rats
- Expression of the Endothelin Receptors in the Hippocampus of SHRSP after Transient Forebrain Ischemia
- Evaluation of the neuroprotective action of WEB 1881 FU on hypoglycemia/hypoxia-induced neuronal damage using rat striatal slices.
- Specific Binding Sites for Endothelins in the Central Nervous System
- Behavioral and electroencephalographic effects of zopiclone, a cyclopyrrolone derivative.
- Localization and Characterization of Specific 125I-Brain Natriuretic Peptide (26) Binding Sites in Adrenal Gland and Kidney
- Inhibitory Effect of NMDA on Dopaminergic Transmission in a Slice Preparation of Rat Globus Pallidus.
- Paracellular Barrier and Tight Junction Protein Expression in the Immortalized Brain Endothelial Cell Lines bEND.3, bEND.5 and Mouse Brain Endothelial Cell 4
- Role of the amygdala in the hippocampal kindling effect of rats.
- Neuroprotective Effect of WEB 1881 FU (Nebracetam) on an Ischemia-Induced Deficit of Glucose Uptake in Rat Hippocampal and Cerebral Cortical Slices and CA1 Field Potential in Hippocampal Slices.
- Specific Binding Sites for Endothelin in the Brain, Spinal Cord, Heart and Kidney
- Nebracetam (WEB 1881FU) Prevents N-Methyl-D-Aspartate Receptor-Mediated Neurotoxicity in Rat Striatal Slices.
- Behavioral effects of brotizolam, a new thienotriazolodiazepine derivative.