Repeated Adenosine Pre-treatment Potentiates the Acute Effect of Methamphetamine in Rats
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概要
- 論文の詳細を見る
Adenosine was intraperitoneally(i.p.)injected to Wistar rats every 3 days with a total of 5 administrations.After a 7−day withdrawal, the animals were challengedwith methamphetamine(0.5 mg/kg, i.p.).The effect of methamphetamine on locomotor activity was significantly potentiated by repeated adenosine pre−treatment.Moreover, methamphetamine−induced dopamine release was also increased in the striatum.Methamphetamine−induced hyperactivity and dopamine release were significantly potentiated by repeated pre−treatment of an adenosine A1 agonist, N6−cyclohexyladenosine(0.5 mg/kg, i.p.).These results suggest that the acute effect of methamphetamine is potentiated by repeated pre−treatment of adenosine via adenosine A1 receptors.
- 社団法人 日本薬理学会の論文
- 2000-09-01
著者
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WATANABE Shigenori
The Department of Pharmacology, Graduate School of Pharmaceutical Science, Kyushu University
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Shimazoe T
Kyushyu Univ. Fukuoka Jpn
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Shimazoe Takao
東京都老人総合研究所
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Shimazoe Takao
Department Of Clinical Physiology Tokyo Metropolitan Institute Of Gerontology
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WATANABE Shigenori
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University
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YOSHIMATSU Akiko
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University
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KAWASHIMO Atsuko
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University
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Shimazoe Takao
The Department Of Pharmacology Graduate School Of Pharmaceutical Science Kyushu University
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Watanabe S
Kyushu Univ. Fukuoka Jpn
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Watanabe Shigenori
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyushu University
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Yoshimatsu Akiko
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyushu University
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Kawashimo Atsuko
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyushu University
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