Behavioral and electroencephalographic effects of zopiclone, a cyclopyrrolone derivative.
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概要
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Behavioral effects of zopiclone were investigated in mice and rats and compared with the data on diazepam, nitrazepam and flurazepam. The electro-encephalographic effect of the drug was also examined in unanesthetized rabbits with chronic electrode implants and compared with that of diazepam. The present results indicate that zopiclone possesses pharmacological properties qualitatively similar to benzodiazepines, which are characterized by potent anticonflict and antiaggressive effects and much weaker anticonvulsant, muscle relaxant, ataxiogenic, sedative and anesthesia potentiating effects; the properties of this drug were compared with those of diazepam, nitrazepam and flurazepam. Zopiclone suppressed the EEG arousal responses and inhibited afterdischarges induced by electrical stimulation of the hippocampus and amygdala. The effects of zopiclone on EEG and afterdischarges were approximately 1/10 those of diazepam.
- 公益社団法人 日本薬理学会の論文
著者
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Shimazoe Takao
Department Of Clinical Physiology Tokyo Metropolitan Institute Of Gerontology
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Shibata Kazuhiko
Department Of Hospital Pharmacy Okayama University Medical School
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Ueki Showa
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyushu University
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Ohta Hisashi
Department Of Electronics Engineering Shibaura Institute Of Technology
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Yamamoto Tsuneyuki
Department Of Developmental Biology Of Hard Tissue Graduate School Of Dental Medicine Hokkaido Unive
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Kataoka Yasufumi
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Watanabe Shigenori
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyushu University
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Shibata Shigenobu
Department Of Pharmacology Faculty Of Human Sciences Waseda University
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OHTA Hisashi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University
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YAMAMOTO Tsuneyuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University
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KATAOKA YASUFUMI
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University
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SHIMAZOE Takao
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University
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KAWAMOTO Hirosuke
Laboratory of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University
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UEKI Showa
Department of Phamacology, Faculty of Pharmaceutical Sciences, Kyushu University
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