Inhibitory effects of condensed tannins on angiotensin converting enzyme.
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概要
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Effects of condensed tannins isolated from Rhei Rhizoma on the activities of angiotensin converting enzyme (ACE) and various proteases were examined in vitro. Among the various condensed tannins tested, procyanidin B-5 3, 3' di-<I>O</I>-gallate and procyanidin C-1 3, 3', 3''-tri-<I>O</I>-gallate strongly inhibited the activity of ACE. The concentration of procyanidin B-5 3, 3'-di-<I>O</I>-gallate required for 50% inhibition of ACE was 1.3×10<SUP>-6</SUP> M. The inhibition of ACE by condensed tannins was reversible and non-competitive, according to dialysis and to Dixon plots. However, over one hundred times the concentration was required to inhibit activities of other proteases such as trypsin, chymotrypsin, leucine aminopeptidase, carboxypeptidase A and urinary kallikrein. These results suggest that the inhibitory effects of condensed tannins on the activities of ACE are specific.
- 公益社団法人 日本薬理学会の論文
著者
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NONAKA Gen-ichiro
Faculty of Pharmaceutical Sciences, Kyushu University
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Nishioka Itsuo
Faculty Of Pharmaceutical Sciences Kyushu University
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Niwa Masami
Department Of Pharmacology 1 Nagasaki University Medical School
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Nonaka Gen-ichiro
Faculty Of Pharmaceutical Sciences Kyushu University
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Ohta Hisashi
Department Of Electronics Engineering Shibaura Institute Of Technology
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OZAKI Masayori
Department of Pharmacology 2, Nagasaki University School of Medicine
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UCHIDA Shinji
On leave from the Yutoku Pharmaceutical Ind. Co.
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IKARI Nobuhiko
Department of Pharmacology 2, Nagasaki University, School of Medicine
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OZAKI Masayori
Department of Pharmacology 2, Nagasaki University, School of Medicine
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NIWA Masami
Department of Pharmacology 2, Nagasaki University, School of Medicine
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Nonaka Gen-ichiro
Faculty of Pharmaceutical Sci Kyushu Univ
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OHTA Hisashi
Department of Pharmacology 2, Nagasaki University, School of Medicine
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Ozaki Masayori
Department of Nutrition Science, Division of Applied Life Sciences, Graduate School of Integrated Science and Art, University of East Asia
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Nishioka Itsuo
Faculty of Pharmaceutical Sci Kyushu Univ
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