A Protective Action of Magnesium Lithospermate B on Renal Function after Ischemia-Reperfusion of Rats and Cultured Proximal Tubular Cells

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The effect of magnesium lithospermate B in ischemic-reperfused rats was examined. In the control rats, blood and renal parameters and the activities of antioxidative enzymes in the renal tissue deviated from the normal range, indicating dysfunction to the kidneys. In contrast, when magnesium lithospermate B was given orally at dose of 10 mg/kg body weight/day for 30 consecutive days prior to this ischemia and reperfusion, the creatinine levels in the serum and renal tissue were lower, while guanidinoacetic acid levels were higher in the treated rats compared to controls; in addition, superoxide dismutase and catalase activity in the renal tissue remained almost as high as that in normal untreated rats. This indicates that the improvement in renal function caused by magnesium lithospermate B is closely related to its antiperoxidation activity, which was confirmed by electron spin resonance findings. In an in vitro model with LLC-PK_1 cells exposed to hypoxia and reoxygenation incubation, magnesium lithospermate B effectively inhibited the leakage of lactate dehydrogenase from the cells, and the formation of malondialdehyde, in a concentration-dependent pattern. Results from both in vivo and in vitro studies have indicated that magnesium lithospermate B can not only protect but also prevent renal dysfunction as a result of ischemia-reperfusion by inhibiting lipid peroxidation. In addition, its membrane-repairing effect suggests that the proximal tubule is one of its possible sites of action.
日本生薬学会の論文
1997-08-20

A Protective Action of Magnesium Lithospermate B on Renal Function after Ischemia-Reperfusion of Rats and Cultured Proximal Tubular Cells

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