Atrial natriuretic peptide-induced inhibition of amiloride-sensitive 22Na+ uptake into cerebral capillaries of spontaneously hypertensive rats.
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概要
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<SUP>22</SUP>Na<SUP>+</SUP> uptake into capillaries isolated from the cerebral cortex of adult (20 to 26-week-old) sustained-hypertensive spontaneously hypertensive rats (SHR) and stroke-prone SHR (SHRSP) was compared with findings in age-matched Wistar Kyoto rats (WKY). In the presence of 1.0 mM ouabain, 1.0 mM furosemide and 2.0 mM LiCl, <SUP>22</SUP>Na<SUP>+</SUP> uptake into the isolated cerebral capillaries of WKY and SHR was significantly reduced to 38% and 65% of the control values, respectively, when 0.1 μM α-rat atrial natriuretic peptide (rANP) was added to the uptake buffer. The rANP-induced inhibition observed in SHR was significantly less, as compared with that in the WKY. Noteworthy was the observation that the Na<SUP>+</SUP> uptake into the cerebral capillaries of SHRSP was not inhibited by rANP. As this peptide is thought to regulate amiloride-sensitive Na<SUP>+</SUP> transport from the blood to brain by interacting with specific receptors, the present finding may relate to the etiology of dysfunction of the blood-brain barrier, in the presence of hypertension.
- 公益社団法人 日本薬理学会の論文
著者
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Niwa Masami
Department Of Pharmacology 1 Nagasaki University Medical School
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OZAKI Masayori
Department of Pharmacology 2, Nagasaki University School of Medicine
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IBARAGI Masa-aki
Department of Pharmacology 2, Nagasaki University School of Medicine
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