Assays of 125I-Bolton-Hunter Substance P Binding Sites, Functional Sites of Tachykinin NK1 Receptor : Quantitative Receptor Autoradiographic Method
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概要
- 論文の詳細を見る
125I -Bolton-Hunter labeled tachykinins, substance P, neurokinin A, and eledoisin have been used as radioligands to differentiate multiple tachykinin receptors 11),12),30). 125I-Bolton- Hunter substance P seems to be a radioligand predominantly recognizing NK1 subtype of tachykinin receptors. As described here, using the quantitative receptor autoradiographic method, the binding sites specifically labeled with the radioligand can be vigorously analyzed. In addition to substance P, neurokinin A and neurokinin B known to be endogenously, new tachykinins, neuropeptide K31) and neuropeptide R32) have been isolated from the porcine brain and rabbit small intestine, respectively. Further characteristics of tachykinin receptors would be clarified with the method described.
- 長崎大学の論文
著者
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Niwa Masami
Department Of Pharmacology 1 Nagasaki University Medical School
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Masami Niwa
Department Of Pharmacology I Nagasaki University School Of Medicine
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