Vulnerability of Synaptic Plasticity in the Striatum of Methamphetamine-Sensitized Rats
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概要
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We examined the influence of ischemia on methamphetamine (MAP)-induced behavioral sensitization and enhancement of dopamine (DA) release. After the recovery period of the ischemia operation, rats were treated with MAP (1 mg/kg, i.p.) once daily for 6 consecutive days. Re-administration of MAP (0.5 mg/kg, i.p.) potentiated the increase of locomotor activity after a 3-day withdrawal and the enhancement of DA release from striatal slices after a 6-day withdrawal. The MAP-induced sensitization was impaired by 5 min ischemia. On the other hand, the increase of locomotor activity induced by single MAP (1 mg/kg, i.p.) administration was impaired by 20 min of ischemia. Moreover, in saline-treated rats the increase of DA release from striatal slices induced by MAP (10 μM) application was also impaired by 20 min of ischemia. These results indicate that the neuronal plastic change may be very vulnerable to ischemia in MAP-induced sensitization.
- 社団法人 日本薬理学会の論文
著者
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WATANABE Shigenori
The Department of Pharmacology, Graduate School of Pharmaceutical Science, Kyushu University
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Shimazoe T
Kyushyu Univ. Fukuoka Jpn
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Shimazoe Takao
東京都老人総合研究所
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Shimazoe Takao
Department Of Clinical Physiology Tokyo Metropolitan Institute Of Gerontology
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WATANABE Shigenori
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University
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SHIBATA Shigenobu
Department of Pharmacology, Faculty of Human Sciences, Waseda University
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ARAI Ikumi
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University
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YOSHIMATSU Akiko
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University
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INOUE Hirotaka
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University
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Shimazoe Takao
The Department Of Pharmacology Graduate School Of Pharmaceutical Science Kyushu University
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Arai Ikumi
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyushu University
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Inoue Hirotaka
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Inoue Hirotaka
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyushu University
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Watanabe S
Kyushu Univ. Fukuoka Jpn
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Watanabe Shigenori
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyushu University
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Shibata S
Department Of Pharmacology Faculty Of Human Sciences Waseda University
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Shibata Shigenobu
Department Of Pharmacology School Of Human Sciences Waseda University
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Yoshimatsu Akiko
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyushu University
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Shibata Shigenobu
Department Of Pharmacology Faculty Of Human Sciences Waseda University
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