Inhibitory Action of 5-HT_<1A> Agonist MKC-242 on Triazolam-Induced Phase Advances in Hamster Circadian Activity Rhythms
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概要
- 論文の詳細を見る
Mammalian circadian rhythms can be entrained by photic and non-photic stimuli. Although we know that non-photic entrainment interferes with photic entrainment signals, there is no information about whether photic entrainment interferes with non-photic entraining signals. We examined whether triazolam (TRZ), a non-photic form of entrainment, could be attenuated by pre-treatment with (S)-5-[3-[(1,4-benzodioxan-2-ylmethyl)amino]propoxy]-1,3-benzodioxole hydrochloride (MKC-242), a photic enhancing drug. We found that TRZ-induced phase advances in hamster behavioral circadian rhythms and the increase of locomotor activity were both significantly attenuated by MKC-242. Thus, in hamsters, the photic enhancing drug MKC-242 seemed to hinder benzodiazepine-induced non-photic entrainment.
- 社団法人 日本薬理学会の論文
- 2005-05-20
著者
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Yokota Shin-ichi
Department Of Microbiology Sapporo Medical University School Of Medicine
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SHIBATA Shigenobu
Department of Pharmacology, Faculty of Human Sciences, Waseda University
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Moriya Takahiro
Division Of Neurobiology And Behavior Department Of Translational Medical Science Course Of Medical
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Moriya Takahiro
Division Of Neurobiology And Behavior Department Of Transiational Medical Sciences Course Of Medical
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Yokota Shin-ichi
Department Of Pharmacology School Of Science And Engineering Waseda University
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Shibata Shigenobu
Department Of Pharmacology School Of Human Sciences Waseda University
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Shibata Shigenobu
Department Of Pharmacology Faculty Of Human Sciences Waseda University
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