Protective Effect of Minaprine against the Abnormal Changes of 2-Deoxyglucose Uptake by Rat Hippocampal Slices Induced by Hypoxia/Hypoglycemia.
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概要
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Effect of minaprine on hypoxia or hypoxia/hypoglycemia (ischemia)-induced impairment of 2-deoxyglucose (2DG) uptake by rat hippocampal slices was evaluated. Since minaprine was found to possess both a stimulating effect on acetylcholine release and a blocking effect on 5-HT<SUB>2</SUB> receptors, the improving effect of minaprine on impaired 2DG uptake was compared to the findings obtained with oxotremorine, ketanserin and pentobarbital. Hippocampal slices were exposed to 20-min ischemia, and then these slices were returned to oxygenated and glucose-containing buffer for 6 hr. Ischemia reduced 30 mM KCl-induced 2DG uptake by the hippocampus. Pretreatment with minaprine, oxotremorine, pentobarbital and ketanserin attenuated the ischemia-induced decline of 2DG uptake. In addition, minaprine, oxotremorine and pentobarbital relatively recovered the increase of 2DG uptake in the hippocampal slices under hypoxia for 45 min. The present results suggest that minaprine exerts a neuroprotective action against ischemia-induced deficit of energy metabolism in vitro.
- 公益社団法人 日本薬理学会の論文
著者
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Shibata Shigenobu
Department Of Pharmacology Faculty Of Human Sciences Waseda University
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UEKI Showa
Department of Phamacology, Faculty of Pharmaceutical Sciences, Kyushu University
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Shibata Shigenobu
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University 62
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Kodama Kohtaroh
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University 62
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