Nootropic Candidates Inhibit Head-Twitches Induced by Mescaline in Mice.
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概要
- 論文の詳細を見る
The effects of various nootropic candidates on mescaline-induced head-twitches were studied in mice. The number of head-twitches induced by mescaline (100 mg/kg, s.c.) was significantly reduced by idebenone (32 and 100 mg/kg, i.p.), minaprine (0.32-10 mg/kg, p.o.) and nebracetam (100 mg/kg, p.o.). Cholinesterase inhibitors such as tetrahydroaminoacridine (1 and 10 mg/kg, p.o.), NIK-247 (10 and 18 mg/kg, p.o.) and physostigmine (0.32 mg/kg, i.p.) also suppressed the head-twitch response to mescaline. These results suggest that the direct or indirect cholinergic-activating effects of these drugs may be involved in inhibiting mescaline-induced head-twitches.
- 公益社団法人 日本薬理学会の論文
著者
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Yamamoto Tsuneyuki
Department Of Developmental Biology Of Hard Tissue Graduate School Of Dental Medicine Hokkaido Unive
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Fujikawa Yasuhiro
Department Of Drug Safety Research Eisai Co. Ltd.
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YATSUGI Shin-ichi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University
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Yatsugi Shin-ichi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University 62
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OHNO Masuo
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University
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UEKI Showa
Department of Phamacology, Faculty of Pharmaceutical Sciences, Kyushu University
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Ohno Masuo
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University 62
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