The effect of agonists at the GABA-benzodiazepine-receptor-complex on the proconflict effect induced by .BETA.-CCM and pentetrazol in rats.

概要

論文の詳細を見る
The effect of anxiolytics, benzodiazepine (BZP), diazepam (DZP), nonBZP zopiclone (ZOP) and phenobarbital (PBT), on the proconflict effect induced by methyl-β-carboline-3-carboxylate (β-CCM) or by pentetrazol (PTZ) was investigated. The proconflict effect of a-CCM and PTZ was reduced by these anxiolytics and aminooxyacetic acid (AOAA). In addition, isoniazid produced proconflict activity. Therefore, it is suggested that anxiolytics facilitate the GABA-ergic function, causing the inhibition of the proconflict effect. Although both propyl-β-carboline-3-carboxylate (β-CCP) and Rol5-1788 did not produce proconflict activity, they reduced the proconflict effect induced by β-CCM but not by PTZ. These data clearly show that β-CCM exerts the proconflict effect through interaction with BZP receptor and that there are behavioral similarities between β-CCP and Rol5-1788. In this study, we additionally observed the time latency until the rat began to drink the water. β-CCM and PTZ prolonged this latency in a dose-dependent manner. However, AOAA could not reduce the prolonged latency induced by β-CCM and by PTZ, and anxiolytics and β-CCP could not reduce the prolonged latency induced by β-CCM. The mechanism of the prolongation of latency induced by β-CCM and PTZ seems to be different from that of the nroconflict effect.
公益社団法人日本薬理学会の論文