INVOLVEMENT OF VITAMIN D IN LEAD-INDUCED CUTANEOUS CALCIFICATION IN RODENTS
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概要
- 論文の詳細を見る
Experimental cutaneous calcification was induced by a subcutaneous injection of lead acetate in parathyroidectomized (PTX) rats and vitamin D-deficient rats whose plasma calcium concentrations were controlled by diets containing various amounts of calcium. Although, in PTX rats, the calcium content of the calcified plaque induced by lead acetate was correlated with their plasma calcium concentration, calcium content of the calcified plaque in vitamin D-deficient rats with normocalcemia was significantly lower than those in control and PTX rats with normocalcemia. A subcutaneous administration of 1α, 25-dihydroxyvitamin D_3 (1α, 25(OH)_2D_3) following the lead acetate injection increased calcium content of the calcified plaque in vitamin D-deficient mice, suggesting the involvement of vitamin D in the cutaneous calcification. As the synthesis of osteocalcin, osteopontin and interleukin-1 (IL-1) receptor is well known to be increased by 1α, 25(OH)_2D_3, gene expressions of mRNAs of these proteins were examined in the skin with calcified plaque by reverse transcription polymerase chain reaction (RT-PCR) analysis. These mRNA expressions in the skin with calcified plaque were increased by a subcutaneous administration of 1α, 25(OH)_2D_3 following the lead acetate injection. On the contrary, they decreased in vitamin D-deficient mice. These findings suggest that vitamin D is directly involved in the process of experimental calcification.
- 日本トキシコロジー学会の論文
- 1998-05-09
著者
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Togari Akifumi
Department of Pharmacology, School of Dentistry, Aichi-Gakuin University
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Togari Akifumi
Department Of Pharmacology School Of Dentistry
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Togari Akifumi
Departments Of Pharmacology School Of Dentistry Aichi-gakuin University
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Togari Akifumi
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Nagoya City University
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Togari Akifumi
Departments Of Anatomy Pharmacology School Of Dentistry Aichi-gakuin University
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INOUE Hirotaka
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University
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Inoue Hirotaka
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Inoue Hirotaka
Department Of Pharmacology School Of Dentistry Aichi-gakuin University
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ARAI Michitsugu
Department of Pharmacology, School of Dentistry, Aichi-Gakuin University
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TSUBOI Takahiro
Department of Pharmacology, School of Dentistry, Aichi-Gakuin University
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Arai Michitsugu
Department Of Pharmacology School Of Dentistry
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Arai Michitsugu
Department Of Pharmacology School Of Dentistry Aichi-gakuin University
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