Both Metabotropic Glutamate I and II Receptors Mediate Augmentation of Dopamine Release From the Striatum in Methamphetamine-Sensitized Rats
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概要
- 論文の詳細を見る
The role of metabotropic glutamate receptor (mGluR) on dopamine overflow from the striatum was studied in methamphetamine (MAP)-sensitized rats. The increase of dopamine release by MAP was significantly inhibited by perfusion of a mGluR antagonist R,S-α-methyl-4-carboxyphenylglycine. The perfused mGluR agonist 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid enhanced the dopamine level. The enhancement was significantly attenuated by co-perfusion of a mGluR group I antagonist (S)-4-carboxy-3-hydroxyphenylglycine or a mGluR group II antagonist R,S-α-methyl-4-tetrazolylphenylglycine. These suggest that both mGluR group I and II mediate augmentation of dopamine release in MAP-sensitized rats.
- 社団法人 日本薬理学会の論文
- 2002-05-01
著者
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WATANABE Shigenori
The Department of Pharmacology, Graduate School of Pharmaceutical Science, Kyushu University
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Shimazoe T
Kyushyu Univ. Fukuoka Jpn
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Shimazoe Takao
東京都老人総合研究所
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Shimazoe Takao
Department Of Clinical Physiology Tokyo Metropolitan Institute Of Gerontology
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WATANABE Shigenori
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University
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DOI YUKIKO
Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University
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ARAI Ikumi
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University
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YOSHIMATSU Akiko
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University
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FUKUMOTO Takako
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University
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Shimazoe Takao
The Department Of Pharmacology Graduate School Of Pharmaceutical Science Kyushu University
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Doi Y
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyushu University
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Doi Yukiko
Department Of Neuroimmunology Research Institute Of Environmental Medicine Nagoya University
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Arai Ikumi
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyushu University
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Watanabe S
Kyushu Univ. Fukuoka Jpn
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Watanabe Shigenori
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyushu University
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Fukumoto Takako
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyushu University
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Yoshimatsu Akiko
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyushu University
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