Enhancement by Morphine of Radiographic Contrast Media-Induced Histamine Release in Rat Peritoneal Mast Cells
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概要
- 論文の詳細を見る
The intravascular application of radiographic contrast media causes hypersensitivity reactions, in which histamine release may play a major role. We examined the interaction between contrast medium and morphine. Among the four nonionic contrast media examined, iopamidol showed the most marked histamine release from rat peritoneal mast cells in vitro. Although iopamidol and morphine themselves did not induce histamine release at concentrations up to 65 mgI/ml and 3 mM, respectively, their combination resulted in a significant histamine release. These findings suggest that patients with exposure to medicines that induce histamine release may have a higher incidence and severity of hypersensitivity reactions to radiographic contrast media.
- 社団法人 日本薬理学会の論文
- 1997-06-01
著者
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Oishi Ryozo
Department of Pharmacy, Kyushu University Hospital
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Hara Tomoko
Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University o
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KATAOKA Yasufumi
Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka U
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Oishi Ryozo
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Hara Tomoko
Department Of Anesthesiology Kitano Hospital
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FUTAGAMI Koujiro
Department of Hospital Pharmacy, Okayama University Medical School
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Oishi R
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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SUEYASU Masanori
Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University
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Futagami Koujiro
Department Of Hospital Pharmacy Okayama University Medical School
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KOMASU Chiharu
Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University
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Kataoka Yasufumi
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Kataoka Yasufumi
Department Of Pharmacology Nagasaki University School Of Medicine
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Futagami Koujiro
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Komasu Chiharu
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Sueyasu M
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Sueyasu Masanori
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Hara Tomoko
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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HARA Tomoko
Department of Anesthesia, The Tazuke Kofukai Medical Research Institute Kitano Hospital
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