Effect of acute treatment of mice with L-histidine on the brain levels of amino acids.
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概要
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The brain histidine level in mice dose-dependently increased 1 and 2 hr after an i.p. injection of 0.5-1.5 g/kg of L-histidine. The treatment with 1.0 and 1.5 g/kg but not 0.5 g/kg of L-histidine significantly decreased the brain levels of tyrosine, phenylalanine and some other amino acids 1 hr later. A complete recovery or a rebound rise of amino acid levels was observed 2 hr after treatment. These results indicate that there is a change in the transport of amino acids into the brain after treatment with large doses of L-histidine.
- 公益社団法人 日本薬理学会の論文
著者
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Oishi Ryozo
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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FURUNO KATSUSHI
Hospital Pharmacy, Okayama University Medical School
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GOMITA YUTAKA
Hospital Pharmacy, Okayama University Medical School
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Saeki Kiyomi
Department Of Pharmacology Okayama University Medical School
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Araki Yasunori
Hospital Pharmacy Okayama University Hospital
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