Effectiveness and Safety of Antiemetic Aprepitant in Japanese Patients Receiving High-Dose Chemotherapy Prior to Autologous Hematopoietic Stem Cell Transplantation
スポンサーリンク
概要
- 論文の詳細を見る
For patients receiving high-dose chemotherapy, a 5-hydroxytryptamine 3 receptor antagonist combined with dexamethasone is a standard antiemetic therapy. Despite this prophylactic anti-emetic treatment, many patients still suffer from uncontrollable emesis. In this study, we retrospectively evaluated the antiemetic effectiveness and safety of aprepitant (a neurokinin-1 receptor antagonist) in addition to 5-HT3 antagonist in Japanese patients with hematologic malignancy receiving high-dose chemotherapy prior to autologous peripheral blood stem cell transplantation (auto-PBSCT). Twenty-six patients received aprepitant and granisetron (the aprepitant group), whereas, 22 patients received granisetron alone (the control group). All patients received 3 mg of granisetron intravenously 30 min before chemotherapy administration. Patients in the aprepitant group additionally received 125 mg of aprepitant 60–90 min before administration of the first moderately to highly emetogenic chemotherapy. On the next day or thereafter, 80 mg of aprepitant was administered in the morning until the last administration of moderately to highly emetogenic anticancer drugs. The percentage of patients who achieved complete response (CR), defined as no emesis with only grade 1–2 nausea, in the aprepitant group was significantly higher than that in the control group (42% vs. 5%, p=0.003). Logistic regression analysis showed that non-prophylactic use of aprepitant was significantly associated with non-CR. The frequencies of adverse drug events (ADEs) were not significantly different between two groups. In conclusion, the results of this study suggest that the addition of aprepitant to granisetron can improve the antiemetic effect without increasing ADEs in patients receiving high-dose chemotherapy prior to auto-PBSCT.
著者
-
Iwasaki Hiromi
Center For Cellular And Molecular Medicine Kyushu University Graduate School Of Medical Sciences
-
Teshima Takanori
Center For Cellular And Molecular Medicine Kyushu University Hospital
-
Oishi Ryozo
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
-
Muta Tsuyoshi
Department Of Clinical Chemistry And Laboratory Medicine Kyushu University
-
Egashira Nobuaki
Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
-
Shiratsuchi Motoaki
Department Of Internal Medicine National Kyushu Center Hospital
-
Ikesue Hiroaki
Department Of Pharmacy Kyushu University Hospital
-
Kato Koji
Department Of Applied Life Science Faculty Of Applied Biological Sciences Gifu University
-
Miyamoto Toshihiro
Department Of Hematology Hamanomachi Hospital
-
Takenaka Katsuto
Department Of Hematology Hamanomachi General Hospital
-
Akashi Koichi
Department of Hematology/Oncology, Kyushu University Hospital, Japan
-
Uchida Mayako
Department of Pharmacy, Kyushu University Hospital
-
Suetsugu Kimitaka
Department of Pharmacy, Kyushu University Hospital
-
Ichinose Kimiko
Unit for Cell Therapy and Transplantation, Kyushu University Hospital
-
Hiraiwa Hiromi
Unit for Cell Therapy and Transplantation, Kyushu University Hospital
-
Sakurai Asako
Unit for Cell Therapy and Transplantation, Kyushu University Hospital
-
KATO Koji
Department of Agricultural Chemistry, Faculty of Agriculture, Gifu University
関連論文
- Neuroprotective Effect of Repeated Treatment with Hericium erinaceum in Mice Subjected to Middle Cerebral Artery Occlusion
- Pulmonary Nocardiosis Developed in a Hematopoietic Stem Cell Transplant Recipient with Bronchiolitis Obliterans
- Retroperitoneoscopic ureterocutaneostomy for obstructive uropathy with advanced bladder cancer : A case report
- Constitutive Activation of Mitogen-activated Protein(MAP) Kinases in Human Renal Cell Carinoma.
- Delta(9)-tetrahydrocannabinol Enhances an Increase of Plasma Corticosterone Levels Induced by Forced Swim-Stress
- New Topics in Vasopressin Receptors and Approach to Novel Drugs : Role of the Vasopressin Receptor in Psychological and Cognitive Functions
- Peripheral blood stem cell versus bone marrow transplantation from HLA-identical sibling donors in patients with leukemia : a propensity score-based comparison from the Japan Society for Hematopoietic Stem Cell Transplantation registry
- Ticlopidine-Associated Thrombotic Thrombocytopenic Purpura With an IgG-Type Inhibitor to von Willebrand Factor-Cleaving Protease Activity
- Oral valganciclovir as preemptive therapy is effective for cytomegalovirus infection in allogeneic hematopoietic stem cell transplant recipients
- Additional acquisition of t(1;21)(p32;q22) in a patient relapsing with acute myelogenous leukemia with NUP98-HOXA9
- Successful treatment of parainfluenza virus 3 pneumonia with oral ribavirin and methylprednisolone in a bone marrow transplant recipient
- Reduced-intensity unrelated donor bone marrow transplantation for hematologic malignancies
- Neuroprotective Effects of Kangen-karyu on Spatial Memory Impairment in an 8-Arm Radial Maze and Neuronal Death in the Hippocampal CA1 Region Induced by Repeated Cerebral Ischemia in Rats
- Per-operative frozen section examination of pelvic nodes is unnecessary for the majority of clinically localized prostate cancers in the prostate-specific antigen era
- Characteristics of Gabexate Mesilate–Induced Cell Injury in Porcine Aorta Endothelial Cells
- Brain metastasis of a papillary renal cell carcinoma, identified as type 2
- Distinct Effects of Omeprazole and Rabeprazole on the Tacrolimus Blood Concentration in a Kidney Transplant Recipient
- High throughput comparative genomic hybridization array analysis of multifocal urothelial cancers
- S14-5 Management of high risk superficial bladder cancer : the timing of radical cystectomy(Symposium 14「Management of Superficial Bladder Cancer」)
- Calcium-Channel Antagonists Inhibit Marble-Burying Behavior in Mice
- Calcineurin Inhibitor-Induced Irreversible Neuropathic Pain after Allogeneic Hematopoietic Stem Cell Transplantation
- 2,5-Dimethoxy-4-iodoamphetamine (DOI) Inhibits Δ^9-Tetrahydrocannabinol-Induced Catalepsy-Like Immobilization in Mice
- Allogeneic cell therapy from immunized donors with tumor antigen peptide enhances the antitumor effect after cyclophosphamide-using non-myeloablative allogeneic hematopoietic cell transplantation
- Evaluation of Effectiveness of New Infusion Set Equipped with an In-line Filter
- Current survey of urinary tuberculosis in Hokkaido, Japan
- Guidelines for urological laparoscopic surgery
- Morbidity of laparoscopic radical prostatectomy : Summary of early multi-institutional experience in Japan
- Successful treatment of refractory advanced nasal NK/T cell lymphoma with unrelated cord blood stem cell transplantation incorporating focal irradiation
- Second unrelated cord blood transplantation using a reduced-intensity conditioning regimen combined with gemtuzumab ozogamicin in patients with relapsed acute myelogenous leukemia
- Quality of life after laparoscopic or open radical prostatectomy : interim report on multi-institutional longitudinal study in Japan
- Retroperitoneal extragonadal germ cell tumor presenting as a bulky pelvic mass of the obturator fossa
- Rituximab for the treatment of corticosteroid-refractory chronic graft-versus-host disease
- Vitamin B_ Deficiency in Patients with Urinary Intestinal Diversion
- Urinary Reconstruction Using Appendix as a Urinary and Catheterizable Conduit in 12 Patients
- Management of Late Complications of Continent Urinary Diversion Using the Kock Pouch and the Indiana Pouch Procedures
- Surgical outcome of laparoscopic radical prostatectomy : summary of early multiinstitutional experience in Japan
- Hypercoagulable State Following Transfusions of Granulocytes Obtained From Granulocyte Colony-Stimulating Factor-Stimulated Donors
- PE-099 Acute Myocardial Infarction as a Systemically Prothrombotic Condition Evidenced by Increased Ratio of von Willebrand Factor to ADAMTS13(Acute coronary syndrome, basic/clinical-5, The 71st Annual Scientific Meeting of the Japanese Circulation Societ
- Rituximab Provided Long-term Remission in a Patient with Refractory Relapsing Thrombotic Thrombocytopenic Purpura
- Intensive Plasma IgG Removal Therapy for Sereve Thrombotic Thrombocytopenic Purpura
- Origin of Basophils and Mast Cells
- Synchronous Testicular Seminoma and Adrenocortical Carcinoma: A Case Report
- Transurethral Electrovaporization of the Prostate: Preliminary Clinical Results with Pressure-Flow Analysis
- Laparoscopic Adrenalectomy for Bilateral Pheochromocytoma: A Case Report
- Effect of Surgical Stress on Immune Function in Patients with Urologic Cancer
- Orthotopic ileal neobladder in male patients: Functional outcomes of 66 cases
- Determination of salicylic acid in human serum with capillary zone electrophoresis
- Clinical and Experimental Evidence for Prevention of Acute Renal Failure Induced by Radiographic Contrast Media
- Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs) : Role of Tryptase/PAR-2 in Vascular Endothelial Barrier Function
- Nafamostat Mesilate Is an Extremely Potent Inhibitor of Human Tryptase
- Gatifloxacin treatment for chronic prostatitis : a prospective multicenter clinical trial
- Prediction of candidates for seminal tract reconstructive surgery among patients with clinically suspected idiopathic or inflammatory obstructive azoospermia
- Absence of Association between E-Cadherin Gene Polymorphism at Position-160 in Promoter Region and Risk of Urothelial Cancer
- Successful treatment of primary aldosteronism due to computed tomography-negative microadenoma
- Potentiation of _L-Dopa-Induced Behavioral Excitement by Histamine H_1-Receptor Antagonists in Mice
- Telomerase activity in urine after transurethral resection of superficial bladder cancer and early recurrence
- Allelic Imbalances on Chromosome 20 in Human Transitional Cell Carcinoma
- Yokukansan Inhibits Social Isolation-Induced Aggression and Methamphetamine-Induced Hyperlocomotion in Rodents(Pharmacology)
- Involvement of GABA_A Receptors in the Neuroprotective Effect of Theanine on Focal Cerebral Ischemia in Mice
- Enantioselective determination of thiamylal in human serum by high-performance liquid chromatography
- Prevalence of human papillomavirus infection in the urinary tract of men with urethritis
- Regional Differences in the Na^+ Reabsorption of Sweat Glands
- Human leukocyte antigen class I down-regulation in muscle-invasive bladder cancer : Its association with clinical characteristics and survival after cystectomy
- Incidence of sexually transmitted diseases in Hokkaido, Japan, 1998 to 2001
- Intracorporeal Lithotripsy with the Swiss Lithoclast
- Application of high-performance thin-layer chromatography for the detection of organophosphorus insecticides in human serum after acute poisoning
- Micellar electrokinetic capillary chromatography for therapeutic drug monitoring of zonisamide
- Enhancement by Morphine of Radiographic Contrast Media-Induced Histamine Release in Rat Peritoneal Mast Cells
- Protective Effects of Amino Acids Against Gabexate Mesilate-Induced Cell Injury in Porcine Aorta Endothelial Cells
- Characteristics of Gabexate Mesilate-Induced Cell Injury in Porcine Aorta Endothelial Cells
- In Vivo Evidence for a Lack of Central Effect of Ebastine, an Antihistaminic Agent, in Rats : a Microdialysis Study
- Familial outbreak of Yersinia enterocolitica serotype O9 biotype 2
- The nationwide study of bacterial pathogens associated with urinary tract infections conducted by the Japanese Society of Chemotherapy
- Ameliorating effects of Kangen-karyu on neuronal damage in rats subjected to repeated cerebral ischemia
- Yokukansan Enhances Pentobarbital-Induced Sleep in Socially Isolated Mice: Possible Involvement of GABAA – Benzodiazepine Receptor Complex
- Simultaneous Left Renal Pelvic and Bilateral Ureteral Tumors Producing Carbohydrate Antigen 19-9
- Mexiletine Reverses Oxaliplatin-Induced Neuropathic Pain in Rats
- EFFECTS OF DELTA-9-TETRAHYDROCANNABINOL ON THE CARDIOVASCULAR SYSTEM, AND PRESSOR AND BEHAVIORAL RESPONSES TO BRAIN STIMULATION IN RATS
- Rapid and sensitive detection of benzodiazepines and zopiclone in serum using high-performance thin-layer chromatography
- Enhancement of antimicrobial activities of cefteram or clavulanic acid/amoxicillin against cefixime-resistant Neisseria gonorrhoeae in the presence of clarithromycin or azithromycin
- Comparison of Peripheral Neuropathy Induced by Standard and Nanoparticle Albumin–Bound Paclitaxel in Rats
- Comparison of Injuring Effects of Vesicant, Irritant, and Nonvesicant Anticancer Drugs on Endothelial Cells
- CENTRAL CHOLINERGIC ACTIVATION BY CHLORFEN VINPHOS, AN ORGANOPHOSPHATE, IN THE RAT
- EFFECT OF DESIPRAMINE ON NORADRENERGIC INHIBITION OF AMYGDALOID EVOKED POTENTIAL
- EFFECT OF STIMULATION OF LOCUS COERULEUS ON THE EVOKED POTENTIAL IN THE AMYGDALA IN RATS
- THE ROLE OF THE LOCUS COERULEUS IN REGULATION OF SEIZURE SUSCEPTIBILITY IN RATS
- Paclitaxel, ifosfamide, and nedaplatin as second-line treatment for patients with metastatic urothelial carcinoma : A phase II study of the SUOC group
- POSSIBLE INVOLVEMENT OF A CENTRAL NORADRENERGIC SYSTEM IN AUTOMUTILATION INDUCED BY CLONIDINE IN MICE
- Diagnostic Value of Serum Procalcitonin and C-reactive Protein for Infections after Allogeneic Hematopoietic Stem Cell Transplantation versus Nontransplant Setting
- Yokukansan Enhances Pentobarbital-Induced Sleep in Socially Isolated Mice : Possible Involvement of GABA_A-Benzodiazepine Receptor Complex
- Advancements in Urology 2011 : A Japanese Urological Association (JUA)/American Urological Association (AUA) Symposium
- Transumbilical approach for laparo-endoscopic single-site adrenalectomy : Initial experience and short-term outcome
- Testis cancer gene D40 expression and its relationship with clinicopathological features in infertile men
- Initial low-dose valganciclovir as a preemptive therapy is effective for cytomegalovirus infection in allogeneic hematopoietic stem cell transplant recipients
- Encephalomyelitis Mimicking Multiple Sclerosis Associated with Chronic Graft-Versus-Host Disease after Allogeneic Bone Marrow Transplantation
- Decrease in Venous Irritation by Adjusting the Concentration of Injected Bendamustine
- Effectiveness and Safety of Antiemetic Aprepitant in Japanese Patients Receiving High-Dose Chemotherapy Prior to Autologous Hematopoietic Stem Cell Transplantation
- Diffuse panbronchiolitis after humanized anti-CCR4 monoclonal antibody therapy for relapsed adult T-cell leukemia/lymphoma
- Unrelated allogeneic bone marrow-derived mesenchymal stem cells for steroid-refractory acute graft-versus-host disease: a phase I/II study